Early-onset baldness and the risk of aggressive prostate cancer: findings from a case–control study

    November 2017 in “ Cancer Causes & Control
    Nathan Papa, Robert J. MacInnis, Dallas R. English, Damien Bolton, Ian D. Davis, Nathan Lawrentschuk, Jeremy Millar, Gianluca Severi, John L. Hopper, Graham G. Giles
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    TLDR Men who start balding at age 20 may have a higher chance of getting aggressive prostate cancer.
    In the 2017 case-control study involving 1,941 men, researchers found that very early-onset androgenetic alopecia (balding at age 20) was associated with a 51% increased risk of developing aggressive prostate cancer, with an odds ratio of 1.51 (95% CI 1.07–2.12). This risk was particularly pronounced for advanced stage prostate cancer, with an odds ratio of 1.68 (95% CI 1.14-2.47). The study suggested that men with early-onset baldness should be considered for earlier prostate cancer screening and urological follow-up. No significant association was found for balding onset at age 40. The study supports the hypothesis of a shared genetic predisposition for both conditions, potentially related to androgen receptor polymorphisms.
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