Diphenylcyclopropenone and Platelet-Rich Plasma in the Management of Severe or Recalcitrant Alopecia Areata

June 2023 in “ Journal of cosmetic dermatology ”

Wafaa Mohamed Abd El‐Magid, Rouga Moumouni Mohamed, Reham Elsharkawy

Diphenylcyclopropenone platelet-rich plasma alopecia areata DPCP PRP AA

From the encyclopedia

Platelet-Rich Plasma →

growth factors taken from your blood and injected into your scalp to stimulate hair

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary This study concluded that both DPCP alone and combined with PRP are effective and safe for treating severe alopecia areata, with no significant difference between the two treatment methods.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study compared the effectiveness of Diphenylcyclopropenone (DPCP) alone versus DPCP combined with platelet-rich plasma (PRP) in treating severe or recalcitrant alopecia areata (AA) in 24 patients. Group A (13 patients) received DPCP alone, while Group B (11 patients) received both DPCP and PRP. After six months, the response rates were 53.85% for Group A and 54.5% for Group B, with no statistically significant difference between the groups. Both treatments were found to be effective and safe, though the study suggested the need for larger sample sizes and longer treatment durations in future research. No serious complications were reported.

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Research cited in this study

18 / 18 results

research Treatment of Chronic Extensive Alopecia Areata by Diphenylcyclopropenone Alone Versus in Combination with Anthralin

10 citations , June 2019 in “Dermatologic therapy”

In this study, treatment with DPCP alone was more effective for hair regrowth and presented fewer side effects in chronic extensive alopecia areata compared to combination therapy with DPCP and anthralin.

research Efficacy and Safety of Anthralin in Combination with Diphenylcyclopropenone in the Treatment of Alopecia Areata: A Retrospective Case Series

20 citations , June 2019 in “Archives of dermatological research”

In this study, combination therapy with DPCP and anthralin promoted hair regrowth in 40.62% of alopecia areata patients who were unresponsive to DPCP alone, with response improving over longer treatment durations.

$Apremilast Is Efficacious in Refractory Alopecia Areata$

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research Clinical Efficacy of Diphenylcyclopropenone in Alopecia Areata: Retrospective Data Analysis of 50 Patients

41 citations , November 2015 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This study found that diphenylcyclopropenone therapy resulted in over 50% hair regrowth in 71% of alopecia totalis patients, with a significant relapse association with thyroid disease, suggesting treatment could be viable but should continue for at least two years.

research Successful Treatment of Corticosteroid-Resistant Ophiasis-Type Alopecia Areata with Platelet-Rich Plasma

30 citations , August 2015 in “JAAD case reports”

This case report describes a patient with corticosteroid-resistant ophiasis alopecia areata who experienced prompt hair regrowth after receiving platelet-rich plasma injections.

Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination with Anthralin in the Treatment of Chronic Extensive Alopecia Areata: A Retrospective Case Series

research Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination with Anthralin in the Treatment of Chronic Extensive Alopecia Areata: A Retrospective Case Series

44 citations , February 2015 in “Journal of the American Academy of Dermatology”

This study found that combination therapy with diphenylcyclopropenone and anthralin was more effective for complete hair regrowth in chronic extensive alopecia areata than diphenylcyclopropenone alone, despite more common side effects.

research Role of Platelet-Rich Plasma in Chronic Alopecia Areata: Our Centre Experience

61 citations , January 2015 in “Indian Journal of Plastic Surgery”

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The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.

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164 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

This study found that PRP injections may improve hair density and reduce hair loss in patients with androgenetic alopecia without significant side effects, but further research is needed to confirm efficacy.

A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

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In this study, platelet-rich plasma significantly increased hair regrowth and reduced symptoms of alopecia areata compared to triamcinolone acetonide or placebo, with no observed side effects.

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This review explores the causes and mechanisms of alopecia areata and discusses current treatments, reporting no new clinical findings.

research Topical Immunotherapy of Severe Alopecia Areata with Diphenylcyclopropenone: Experience in an Iranian Population

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This study found that topical diphenylcyclopropenone was effective in treating severe alopecia areata but had a high relapse rate and was often accompanied by side effects like eczema and lymphadenopathy.