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    Preferential Crosstalk Between Perifollicular Capillary Vessels and Dermal Papilla Cells During Hair Cycling Homeostasis

    October 2025 in “ Research Square (Research Square) ”
    Ying Zeng, Akinari Abe, Satsuki Takashima … Ken‐ichi Mizutani

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that perifollicular vascularization adapts to physiological changes, with minoxidil enhancing capillary growth around the dermal papilla and aging-related factors inhibiting it, suggesting potential interventions for hair loss.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 14

    1. Crosstalk Between Endothelial Cells and Dermal Papilla Entails Hair Regeneration and Angiogenesis During Aging Journal of Advanced Research · 2024
    2. Mechanical Stimuli-Induced CCL2 Restores Adult Mouse Cells to Regenerate Hair Follicles Molecular Therapy — Nucleic Acids · 2023
    3. Vitamins and Their Derivatives Synergistically Promote Hair Shaft Elongation via PlGF/VEGFR-1 Signalling Activation Journal of dermatological science · 2022
    4. Hair Follicle Germs Containing Vascular Endothelial Cells for Hair Regenerative Medicine Scientific Reports · 2021
    5. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    6. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    7. Perivascular Hair Follicle Stem Cells Associate With a Venule Annulus Journal of Investigative Dermatology · 2013
    8. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    9. Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation Pigment Cell & Melanoma Research · 2011
    10. Chemotherapy Targets the Hair Follicle Vascular Network but Not the Stem Cells Journal of Investigative Dermatology · 2006
    11. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    12. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    13. Current Understanding of Androgenetic Alopecia: Part I - Etiopathogenesis PubMed · 2000
    14. Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999