Preferential Crosstalk Between Perifollicular Capillary Vessels and Dermal Papilla Cells During Hair Cycling Homeostasis

October 2025 in “ Research Square (Research Square) ”

Ying Zeng, Akinari Abe, Satsuki Takashima, Masahiro Kono, Reina Kagiyama, Mariko Komabayashi‐Suzuki, Mariko Moriyama, Hiroyuki Moriyama, Tadashi Okamoto, Hideya Ando, Masaki Tanaka, Masamitsu Ichihashi, Masatsugu Ema, Ken‐ichi Mizutani

perifollicular vascularization dermal papilla minoxidil vascular endothelial cells angiogenic chemokine CCL2 hair cycling homeostasis vessel-DP crosstalk CCL2-neutralizing antibodies Rogaine

TLDR Enhancing blood vessel interactions with hair cells may help treat hair loss and skin aging.

This study highlights the dynamic role of perifollicular vascularization in hair cycling homeostasis, emphasizing the preferential mobilization of capillary vessels around the dermal papilla (DP). Minoxidil treatment enhanced this mobilization, while aging models showed inhibition. Vascular endothelial cells induced angiogenic chemokine expression, such as CCL2, in DP cells, enhancing vessel-DP crosstalk. CCL2 levels fluctuated with hair cycles and decreased in aged skin, with CCL2-neutralizing antibodies reducing vascularization and DP function. These findings suggest that enhancing vessel-DP interactions could be a therapeutic target for hair loss and skin aging.

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