Preferential Crosstalk Between Perifollicular Capillary Vessels and Dermal Papilla Cells During Hair Cycling Homeostasis

October 2025 in “ Research Square (Research Square) ”

Ying Zeng, Akinari Abe, Satsuki Takashima, Masahiro Kono, Reina Kagiyama, Mariko Komabayashi‐Suzuki, Mariko Moriyama, Hiroyuki Moriyama, Tadashi Okamoto, Hideya Ando, Masaki Tanaka, Masamitsu Ichihashi, Masatsugu Ema, Ken‐ichi Mizutani

perifollicular vascularization dermal papilla minoxidil vascular endothelial cells angiogenic chemokine CCL2 hair cycling homeostasis vessel-DP crosstalk CCL2-neutralizing antibodies Rogaine

Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

Studysummary This study found that perifollicular vascularization adapts to physiological changes, with minoxidil enhancing capillary growth around the dermal papilla and aging-related factors inhibiting it, suggesting potential interventions for hair loss.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Crosstalk Between Endothelial Cells and Dermal Papilla Entails Hair Regeneration and Angiogenesis During Aging

May 2024 in “Journal of Advanced Research”

In this study, researchers found that the interaction between dermal papilla and endothelial cells decreases with age, affecting signaling pathways that promote hair regeneration and angiogenesis in mouse models.

research Mechanical Stimuli-Induced CCL2 Restores Adult Mouse Cells to Regenerate Hair Follicles

18 citations , March 2023 in “Molecular Therapy — Nucleic Acids”

In this study, adding CCL2 protein to organoid cultures helped adult skin cells regain the ability to self-organize and regenerate hair follicles, suggesting potential therapeutic applications.

research Vitamins and Their Derivatives Synergistically Promote Hair Shaft Elongation via PlGF/VEGFR-1 Signalling Activation

1 citations , September 2022 in “Journal of dermatological science”

This study found that a combination of vitamins in hair care products promoted hair shaft elongation in a mouse model by activating the PlGF/VEGFR-1 signaling pathway.

research Hair Follicle Germs Containing Vascular Endothelial Cells for Hair Regenerative Medicine

23 citations , January 2021 in “Scientific Reports”

In this study, hair follicle germs containing vascular endothelial cells showed improved hair regeneration and morphogenesis-related gene expression in mice, suggesting a promising strategy for hair regenerative medicine.

Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

research Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

46 citations , April 2016 in “Journal of Investigative Dermatology”

This study suggests that down-regulation of vasculature-related genes in dermal papilla cells from balding scalps might contribute to the development of androgenetic alopecia.

The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

research The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

149 citations , July 2014 in “Cold Spring Harbor Perspectives in Medicine”

This article provides contact information for Bruce A. Morgan and features no new research findings.

research Perivascular Hair Follicle Stem Cells Associate With a Venule Annulus

51 citations , April 2013 in “Journal of Investigative Dermatology”

Hair follicle stem cells rely on nearby blood vessels for their maintenance and function.

research Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

305 citations , June 2012 in “Nature”

This study reports that hair regeneration in live mice involves spatially regulated stem cell divisions and requires mesenchymal interactions, observed in real-time using a novel non-invasive imaging method.

research Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation

240 citations , April 2011 in “Pigment Cell & Melanoma Research”

This review discusses the identification and characteristics of melanocyte stem cells, emphasizing their role in hair pigmentation, greying, and skin repigmentation, but reports no new research findings.

research Chemotherapy Targets the Hair Follicle Vascular Network but Not the Stem Cells

45 citations , July 2006 in “Journal of Investigative Dermatology”

This study found that doxorubicin disrupts hair-follicle-associated blood vessels, which may contribute to hair follicle dystrophy and alopecia in mice, but hair-follicle stem cells remained unaffected.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

This article reviews the mechanisms by which minoxidil stimulates hair growth and reports no new clinical findings.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

This study found that VEGF significantly enhances perifollicular vascularization during the hair growth phase, accelerating hair regrowth and increasing follicle and hair size, while its inhibition retards hair growth.

research Current Understanding of Androgenetic Alopecia: Part I - Etiopathogenesis

28 citations , June 2000 in “PubMed”

This article reviews the molecular mechanisms involved in androgenetic alopecia, focusing on the role of type 2 5α-reductase and DHT, but presents no new findings.

research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

231 citations , December 1999 in “Journal of Investigative Dermatology”

This study found that the volume of a hair follicle's dermal papilla is strongly correlated with its size, primarily due to the number of cells it contains and the volume of extracellular matrix.