Immunomodulatory Potential and Biocompatibility of Chitosan-Hydroxyapatite Biocomposites for Tissue Engineering
June 2025
in “
Journal of Composites Science
”
chitosan hydroxyapatite biocomposites tissue engineering inflammatory conditions biocompatibility immunomodulatory properties hydrogel cell viability cytotoxicity immune responses anti-inflammatory cytokines pro-inflammatory cytokines in vivo studies rat dermatitis model inflammation tissue regeneration chronic inflammatory skin conditions CS-HAp skin inflammation skin regeneration
Studysummary This study investigated chitosan–hydroxyapatite biocomposites, finding them to enhance anti-inflammatory cytokine expression, support cellular activities, and reduce pro-inflammatory cytokines in a dermatitis model, while highlighting gaps in understanding their immune modulation and issues with reproducibility for clinical use.
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