Investigating Potential Causal Relationships Between Plasma Protein Ratios and Alopecia Areata: A Bidirectional Mendelian Randomization Study

    September 2025 in “ British Journal of Hospital Medicine ”
    Xiaoqi Tan, Zhen Yin, Shiyu Zhu, Liehua Deng
    Studysummary This study found that certain plasma protein ratios, specifically AGRN/HSPG2 and DECR1/FKBP1B, were significantly associated with an increased risk of alopecia areata, indicating potential causal relationships but reverse causality was not supported.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on magonlinelibrary.com →
    Discuss this study in the Community →

    Research cited in this study 11

    1. Progress on Mitochondria and Hair Follicle Development in Androgenetic Alopecia: Relationships and Therapeutic Perspectives Stem Cell Research & Therapy · 2025
    2. Intermittent Fasting Triggers Interorgan Communication To Suppress Hair Follicle Regeneration Cell · 2024
    3. Deciphering the Complex Immunopathogenesis of Alopecia Areata International Journal of Molecular Sciences · 2024
    4. Aberrant Inflammasome Activation as a Driving Force of Human Autoimmune Skin Disease Frontiers in immunology · 2023
    5. Regulation of Stem Cell Fate by HSPGs: Implication in Hair Follicle Cycling npj Regenerative Medicine · 2022
    6. Evaluation of the Serum C-Reactive Protein–Albumin Ratio and Its Relationship with Disease Severity in Alopecia Areata: A Prospective Case–Control Study Journal of Cosmetic Dermatology · 2022
    7. The Associated Burden of Mental Health Conditions in Alopecia Areata: A Population-Based Study in UK Primary Care British Journal of Dermatology · 2022
    8. Observations Suggesting a Contribution of Altered Dermal Papilla Mitochondrial Function to Androgenetic Alopecia Experimental Dermatology · 2022
    9. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    10. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    11. Alopecia Areata: A Comprehensive Review of Pathogenesis and Management Clinical Reviews in Allergy & Immunology · 2017