TLDR People with rheumatoid arthritis have a higher risk of developing alopecia areata.
This study utilized Mendelian randomization to explore the causal relationship between rheumatoid arthritis (RA) and alopecia areata (AA) using large-scale genome-wide association study data, with 58,284 participants for RA and 361,822 for AA. The analysis, primarily using the inverse variance-weighted method, found a significant association between genetically predicted RA and an increased likelihood of AA, with an odds ratio of 1.21. The results were consistent across different methods, indicating a robust association without influence from other genetic factors. The study suggests that individuals with RA should be aware of the potential risk of developing AA, emphasizing the importance of regular monitoring and early detection.
32 citations
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March 2015 in “The Journal of Clinical Endocrinology & Metabolism” Alopecia areata is linked to thyroid autoimmunity but not type 1 diabetes.
52 citations
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September 2014 in “Nature medicine” JAK inhibitors might help treat alopecia areata.
701 citations
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August 2014 in “Nature medicine” Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.
109 citations
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June 2000 in “Development” Notch pathway activation causes abnormal hair layer development.
5 citations
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May 2023 in “Frontiers in immunology” Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.
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March 2023 in “Frontiers in immunology” Atopic dermatitis increases the risk of some autoimmune diseases.
Higher levels of β-carotene and vitamin E may help prevent certain types of hair loss.
64 citations
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March 2017 in “Nature communications” Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.
16 citations
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January 2022 in “International journal of molecular sciences” Certain daily habits like stress, diet, and sleep can affect the severity of hair loss in alopecia areata.
