Partial Alopecia Area Retains Bulge Hair Follicle Progenitor Cells in Indian Androgenetic Alopecia Patients

    Akshay Hegde, Dyuti Saha, Savitha Somaiah, Colin Jamora
    Studysummary This study found that partially bald scalps of Indian men with androgenic alopecia retain progenitor cells marked by CD34 and Sox9, but these cells are absent in completely bald areas, suggesting that interventions might be more effective if focused on early-stage hair loss.
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    Research cited in this study 15

    1. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    2. Progenitor-Cell-Enriched Micrografts as a Novel Option for the Management of Androgenetic Alopecia Journal of Cellular Physiology · 2019
    3. Expert Consensus on the Management of Androgenetic Alopecia in India International Journal of Trichology · 2019
    4. Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia Molecular and Cellular Endocrinology · 2016
    5. Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia Journal of Dermatological Treatment · 2016
    6. Mapping the Expression of Epithelial Hair Follicle Stem Cell-Related Transcription Factors LHX2 and SOX9 in the Human Hair Follicle Experimental Dermatology · 2015
    7. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    8. Androgenetic Alopecia: An Update Indian Journal of Dermatology, Venereology and Leprology · 2013
    9. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    10. Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities British Journal of Dermatology · 2010
    11. Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects International Journal of Trichology · 2009
    12. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    13. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    14. Androgenetic Alopecia in Men and Women Clinics in Dermatology · 2001
    15. The Transverse Anatomy of Androgenic Alopecia The Journal of Dermatologic Surgery and Oncology · 1990