Effectiveness of Biotin Supplementation for Hair Growth in Patients with Alopecia: A Systematic Review

    May 2026 in “ Dermato ”
    Pedro Moltó-Balado, Andrea Simeó-Monzó, Alba del Barrio-González
    Studysummary This systematic review found no consistent evidence supporting the effectiveness of biotin supplementation for alopecia treatment unless there is a documented deficiency.
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    Research cited in this study 13

    1. The Clinical Evaluation of Serum WS Biotin, a Novel Encapsulated Form of D-Biotin With Improved Water Solubility, for Anti-Hair Shedding Applications. A Prospective Single-Arm, Nonrandomized, Pretest-Posttest Study Health Science Reports · 2025
    2. A Comprehensive Investigation of Biochemical Status in Patients with Telogen Effluvium: Analysis of Hb, Ferritin, Vitamin B12, Vitamin D, Thyroid Function Tests, Zinc, Copper, Biotin, and Selenium Levels Journal of Cosmetic Dermatology · 2024
    3. Efficacy of 5% Topical Minoxidil Versus 5 Mg Oral Biotin Versus Topical Minoxidil and Oral Biotin on Hair Growth in Men: Randomized, Crossover, Clinical Trial Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2024
    4. Trends in Hair, Skin, and Nails Supplement Use: Data from the National Health and Nutrition Examination Survey 2011-2020 Journal of the American Academy of Dermatology · 2023
    5. Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss JAMA dermatology · 2022
    6. Efficacy of Intramuscular Injections of Biotin and Dexpanthenol in the Treatment of Diffuse Hair Loss: A Randomized, Double-Blind Controlled Study Comparing Two Brands Dermatologic Therapy · 2022
    7. Evaluation of Biophysical Skin Parameters and Hair Changes in Patients with Acne Vulgaris Treated with Isotretinoin, and the Effect of Biotin Use on These Parameters International Journal of Dermatology · 2021
    8. Risks of Skin, Hair, and Nail Supplements Dermatology practical & conceptual · 2020
    9. Hair Loss After Sleeve Gastrectomy and Effect of Biotin Supplements Journal of Laparoendoscopic & Advanced Surgical Techniques · 2020
    10. Serum Biotin and Zinc in Male Androgenetic Alopecia Journal of Cosmetic Dermatology · 2019
    11. The Role of Vitamins and Minerals in Hair Loss: A Review Dermatology and Therapy · 2018
    12. A Review of the Use of Biotin for Hair Loss Skin appendage disorders · 2017
    13. Serum Biotin Levels in Women Complaining of Hair Loss International Journal of Trichology · 2016