Biocomposite nanofiber matrices to support ECM remodeling by human dermal progenitors and enhanced wound closure

The study investigated the use of novel modifiable nanofiber scaffolds made from Poly (ε-caprolactone) (PCL) and gelatin (GE) to enhance skin wound healing. These scaffolds were designed to support the delivery and distribution of adult human Skin-derived Precursor Cells (hSKPs) across wound beds. The composite scaffolds, created through electrospinning, demonstrated unique morphological and mechanical properties that promoted extracellular matrix protein deposition and increased cell proliferation, spreading, and integration. When transplanted into wounds, the acellular scaffolds improved dermal-epidermal thickness, axonal density, and collagen deposition, indicating their potential as effective cell delivery systems for wound healing.