Androgenetic Alopecia: New Insights into the Pathogenesis and Mechanism of Hair Loss

    January 2016
    Rodney Sinclair, Niloufar Torkamani, Leslie Jones
    Studysummary This study presents a new model for the progression of androgenetic alopecia, suggesting that the loss of attachment between the bulge's stem cells and the arrector pili muscle may contribute to irreversible hair miniaturization.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 12

    1. Hair Shedding in Women: How Much Is Too Much? British Journal of Dermatology · 2015
    2. Destruction of the Arrector Pili Muscle and Fat Infiltration in Androgenic Alopecia British Journal of Dermatology · 2014
    3. Beyond Goosebumps: Does the Arrector Pili Muscle Have a Role in Hair Loss? International Journal of Trichology · 2014
    4. Miniaturized Hairs Maintain Contact With the Arrector Pili Muscle in Alopecia Areata but Not in Androgenetic Alopecia: A Model for Reversible Miniaturization and Potential for Hair Regrowth International Journal of Trichology · 2012
    5. Single Follicular Unit Transplantation Reconstructs Arrector Pili Muscle and Nerve Connections and Restores Functional Hair Follicle Piloerection The Journal of Dermatology · 2012
    6. The Ludwig Pattern of Androgenetic Alopecia Is Due to a Hierarchy of Androgen Sensitivity Within Follicular Units That Leads to Selective Miniaturization and a Reduction in the Number of Terminal Hairs Per Follicular Unit British Journal of Dermatology · 2008
    7. Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations British Journal of Dermatology · 2006
    8. Prevalence of Male and Female Pattern Hair Loss in Maryborough Journal of Investigative Dermatology Symposium Proceedings · 2005
    9. The Reliability of Horizontally Sectioned Scalp Biopsies in the Diagnosis of Chronic Diffuse Telogen Hair Loss in Women Journal of The American Academy of Dermatology · 2004
    10. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    11. Cellular And Developmental Aspects Of Androgenetic Alopecia Experimental Dermatology · 1998
    12. Fortnightly Review: Male Pattern Androgenetic Alopecia BMJ · 1998

    Related research 15

    1. Beyond Goosebumps: Interactions Between the Hair Follicle, the Arrector Pili Muscle, and the Sympathetic Nerve During Development and Hair Follicle Regeneration Journal of Investigative Dermatology · 2018
    2. Comparative Transcriptome Profiling Provides New Insights Into Mechanisms of Androgenetic Alopecia Progression British Journal of Dermatology · 2016
    3. Biology of the Hair Follicle and Mechanisms of Nonscarring and Scarring Alopecia Seminars in cutaneous medicine and surgery · 2015
    4. Cell Biology and Disease of Hair Follicle: Pathomechanism and Treatment of Androgenetic Alopecia The Nishinihon Jourrnal of Dermatology · 2013
    5. Miniaturized Hairs Maintain Contact With the Arrector Pili Muscle in Alopecia Areata but Not in Androgenetic Alopecia: A Model for Reversible Miniaturization and Potential for Hair Regrowth International Journal of Trichology · 2012
    6. Stem Cells and Alopecia: A Review of Pathogenesis British Journal of Dermatology · 2012
    7. Single Follicular Unit Transplantation Reconstructs Arrector Pili Muscle and Nerve Connections and Restores Functional Hair Follicle Piloerection The Journal of Dermatology · 2012
    8. Male Androgenetic Alopecia Is Due to Hair Follicle Stem Cell Inactivation Expert Review of Dermatology · 2011
    9. Inflammatory Phenomena and Fibrosis in Androgenetic Alopecia Springer eBooks · 2010
    10. Male Pattern Baldness: An Update Revista de Ciências Médicas · 2009
    11. The Genetically Programmed Hair Growth Cycle And Alopecia: What Is There To Know? Expert Review of Dermatology · 2006
    12. Pathobiology of Androgenetic Alopecia Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic · 2003
    13. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    14. Cellular And Developmental Aspects Of Androgenetic Alopecia Experimental Dermatology · 1998
    15. Androgenetic Alopecia: Some Thoughts and Views About Its Topical Treatment Springer eBooks · 1989