Androgenetic Alopecia: New Insights into the Pathogenesis and Mechanism of Hair Loss

January 2016

Rodney Sinclair, Niloufar Torkamani, Leslie Jones

androgenetic alopecia AGA arrector pili muscle bulge stem cell population miniaturization alopecia areata

TLDR The arrector pili muscle plays a key role in hair loss in androgenetic alopecia.

The document discussed new insights into the pathogenesis of androgenetic alopecia (AGA), highlighting the role of the arrector pili muscle in hair loss. It was previously thought to be inactive in hair disease, but 3D reconstructions showed its involvement in the diffuse hair loss seen in women with AGA, as opposed to the patterned baldness in men. The study suggested that the loss of attachment between the bulge stem cell population and the arrector pili muscle explained the irreversible miniaturization in AGA, unlike in alopecia areata. A new model for AGA progression was proposed.

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Research cited in this study

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 759 upvotes 3 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Confused why people are calling PP405 a cure...it never claimed to be able to undo miniaturization or revert vellus back to terminal hairs. It seems to be more of a growth stimulant like minoxidil.

in Research/Science 53 upvotes 3 weeks ago

PP405 is not a cure for hair loss but may reactivate dormant hair follicles, similar to minoxidil. It is unlikely to help with miniaturized or vellus hairs and is still in trial phases, with availability expected around 2030.

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in Research 413 upvotes 1 month ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 2 upvotes 1 month ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community New Treatments, and a Huge Group Buy with Lots of Research

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A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

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