Beyond Goosebumps: Interactions Between the Hair Follicle, the Arrector Pili Muscle, and the Sympathetic Nerve During Development and Hair Follicle Regeneration

May 2018 in “ Journal of Investigative Dermatology ”

Yulia Shwartz, M. Gonzalez Celeiro, Chunhui Chen, Simon Lin, Yung-Yuan Hsu

hair follicle arrector pili muscle sympathetic nerve hair follicle stem cell permanent hair loss de novo methylation DNA methylation hair follicle cycling epidermal homeostasis Wnt signaling B-catenin signaling hair follicle initiation stem cell skin homeostasis

TLDR Arrector pili muscle regulates hair follicle stem cells, DNA methylation needed for hair cycling, and Wnt/B-catenin signaling starts hair growth.

This document discusses three studies related to hair follicle development and regeneration. The first study found that the arrector pili muscle plays a crucial role in regulating hair follicle stem cell activity during regeneration and is associated with permanent hair loss conditions. The second study found that de novo methylation of DNA is required for proper hair follicle cycling and epidermal homeostasis. The third study found that Wnt/B-catenin signaling is essential for hair follicle initiation.

View this study on jidonline.org →

Discuss this study in the Community →

5 / 5 results

research Recent Progress in Understanding the Effect of Sympathetic Nerves on Hair Follicle Growth

4 citations , August 2021 in “Frontiers in Cell and Developmental Biology”

Stress can cause hair loss by affecting nerve-related hair growth, and noradrenaline might help prevent this.

research Environment of the Anagen Follicle

4 citations , January 2018 in “Advances in Experimental Medicine and Biology”

The document concludes that hair follicles have a complex environment and our understanding of it is growing, but there are limitations when applying animal study findings to humans.

research Promoting Effect of Hair Follicle Stem Cells in the Wound Healing of Skin

December 2017 in “Chin J Cell Stem Cell (Electronic Edition)”

Hair follicle stem cells help skin wounds heal faster.

research Single Follicular Unit Transplantation Reconstructs Arrector Pili Muscle and Nerve Connections and Restores Functional Hair Follicle Piloerection

13 citations , March 2012 in “The Journal of Dermatology”

Hair transplant surgery can rebuild muscle and nerve connections, allowing transplanted hairs to stand up like normal hairs.

research Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme During the Hair Growth Cycle: Implications for Growth Control and Hair Follicle Transformations

54 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Disruptions in hair follicle fibroblast dynamics can cause hair growth problems.