Beyond Goosebumps: Interactions Between the Hair Follicle, the Arrector Pili Muscle, and the Sympathetic Nerve During Development and Hair Follicle Regeneration

April 2018 in “ Journal of Investigative Dermatology ”

Yulia Shwartz, M. Gonzalez Celeiro, Chunhui Chen, Simon Lin, Yung-Yuan Hsu

hair follicle arrector pili muscle sympathetic nerve hair follicle stem cell permanent hair loss de novo methylation DNA methylation hair follicle cycling epidermal homeostasis Wnt signaling B-catenin signaling hair follicle initiation stem cell skin homeostasis

TLDR Arrector pili muscle regulates hair follicle stem cells, DNA methylation needed for hair cycling, and Wnt/B-catenin signaling starts hair growth.

This document discusses three studies related to hair follicle development and regeneration. The first study found that the arrector pili muscle plays a crucial role in regulating hair follicle stem cell activity during regeneration and is associated with permanent hair loss conditions. The second study found that de novo methylation of DNA is required for proper hair follicle cycling and epidermal homeostasis. The third study found that Wnt/B-catenin signaling is essential for hair follicle initiation.

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