Alopecia areata: Pathogenesis and treatment

    Andrew J. Mitchell, Edward A. Krull
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    TLDR No single treatment is consistently effective for alopecia areata, and more research is needed.
    The document reviewed the pathogenesis and treatment of alopecia areata, an autoimmune condition causing hair loss. It highlighted the role of immune system dysfunction, particularly T-cell subpopulations, and their cytotoxic activities. Various treatments were explored, including systemic and topical corticosteroids, immunotherapy agents like DNCB and SADBE, and minoxidil, with varying degrees of success. While some treatments showed promise, such as photochemotherapy with a 60%-70% success rate and minoxidil with 81% effectiveness in one study, no single treatment was consistently effective. The review underscored the complexity of alopecia areata and the need for further research to improve treatment efficacy.
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    Cited in this study

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      Photochemotherapy and Alopecia Areata

      research Photochemotherapy and Alopecia Areata

      10 citations ,   May 1983 in “International Journal of Dermatology”
      Some people with severe hair loss saw hair regrowth after a specific light and drug treatment.
      Diseases of the hair and scalp

      research Diseases of the hair and scalp

        January 1983 in “Journal of The American Academy of Dermatology”
      The book is a valuable resource for understanding hair and scalp problems but could be updated with more information on certain conditions.
      Topical Minoxidil in Alopecia Areata

      research Topical Minoxidil in Alopecia Areata

      56 citations ,   August 1981 in “Journal of The American Academy of Dermatology”
      Minoxidil helps hair regrowth in alopecia areata safely.

      research Minoxidil

      45 citations ,   January 1981 in “Annals of Internal Medicine”
      Minoxidil controls blood pressure effectively, but may cause side effects like hypertrichosis.
      Alopecia Totalis

      research Alopecia Totalis

      22 citations ,   March 1963 in “Archives of dermatology”
      A woman regrew her hair significantly using a corticosteroid cream with a plastic cover.


    1 / results