A Human Folliculoid Microsphere Assay for Exploring Epithelial– Mesenchymal Interactions in the Human Hair Follicle
This pilot study introduced a novel organotypic assay using human folliculoid microspheres (HFMs) to explore epithelial-mesenchymal interactions in human hair follicles. HFMs, composed of human dermal papilla fibroblasts and outer root sheath keratinocytes within an extracellular matrix, retained key interactions characteristic of human scalp hair follicles. The study demonstrated that HFMs could be used to assess the effects of hair growth-modulatory agents on relevant hair growth markers under simplified in vitro conditions. Additionally, HFMs proved useful for identifying target genes and products for potential hair growth drugs, making them a valuable tool for both basic and applied hair research.
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