Cell Death in the Skin: Mechanisms and Implications

February 2009 in “ Apoptosis ”

Saskia Lippens, Esther Hoste, Peter Vandenabeele, Patrizia Agostinis, Wim Declercq

apoptosis keratinocytes hair follicles NF-kB UV radiation DNA damage p53 protein skin homeostasis cornification inflammatory conditions skin diseases cancer therapy autoimmune diseases

Studysummary This review examines apoptotic and anti-apoptotic mechanisms in skin homeostasis and related diseases but presents no new research findings.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression

research Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression

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research Keratin 17 Null Mice Exhibit Age- And Strain-Dependent Alopecia

122 citations , June 2002 in “Genes & Development”

This study found that K17 is crucial for the structural integrity and survival of hair-producing cells, with K17 null mice developing alopecia due to hair fragility and follicular alterations.

research A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression

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research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

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