The Rho GTPase Regulator ARHGEF3 Orchestrates Hair Placode Budding by Coordinating Cell Fate and P-Cadherin Patterning in Mice

    January 2026 in “ PLoS Biology ”
    Krithika Kalyanakrishnan, Amy Beaudin, Alexandra Jetté … Mélanie Laurin
    Studysummary This study used developing mouse hair follicles to explore early epithelial bud formation, finding that the Rho GTPase regulator ARHGEF3 plays a crucial role in regulating cell fate and cadherin patterning, with knockouts showing disrupted morphology and increased straight hair follicle growth.
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    Research cited in this study 9

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