Formulation Optimization, In Vitro and In Vivo Evaluation of Niosomal Nanocarriers for Enhanced Topical Delivery of Cetirizine

    August 2023 in “ Saudi Pharmaceutical Journal ”
    Mohammed F. Aldawsari, El‐Sayed Khafagy, Ehssan Moglad, Amr S. Abu Lila
    Studysummary This study found that cetirizine-loaded niosomal gels demonstrated superior skin deposition and retention compared to plain cetirizine gel, suggesting potential for improved topical management of alopecia.
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    Research cited in this study 12

    1. Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-Blind Controlled Study Journal of Pharmacy and Pharmaceutical Sciences · 2021
    2. Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages Drug Design Development and Therapy · 2020
    3. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    4. Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery Pharmaceutics · 2019
    5. A Preliminary Study on Topical Cetirizine in the Therapeutic Management of Androgenetic Alopecia Journal of Dermatological Treatment · 2017
    6. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    7. Androgenetic Alopecia: A Review Endocrine · 2017
    8. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    9. Niosomes as a Vesicular Carrier for Topical Administration of Minoxidil: Formulation and In Vitro Assessment Drug Delivery and Translational Research · 2013
    10. Niosomes as a Promising Carrier for Topical Drug Delivery Expert Opinion on Drug Delivery · 2012
    11. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    12. Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery International Journal of Pharmaceutics · 2009