Exogenous Alpha-Ketoglutaric Acid Alleviates Rabbit Dermal Papilla Cell Oxidative Damage Caused by Hydrogen Peroxide Through the ERK/Nrf2 Signaling Pathway

April 2025 in “ Antioxidants ”

Xiaosong Wang, Shu Li, Jiali Chen, Lei Liu, Fuchang Li

alpha-ketoglutarate AKG Dermal Papilla Cells hydrogen peroxide H2O2 reactive oxygen species ROS mitochondrial function apoptosis Bcl-2/Bax ratio antioxidant levels ERK/Nrf2 signaling pathway Nrf2 activity oxidative stress α-ketoglutarate DPCs

Studysummary This study found that α-ketoglutarate protected dermal papilla cells from oxidative stress by enhancing the Nrf2 pathway and mitigating cell damage through the ERK/Nrf2 axis.

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