Evaluation of the Protection of Astaxanthin on Human Hair Follicle Papilla Cells Against the Aging Effects Triggered by Hydrogen Peroxide

September 2024 in “ Vietnam Journal of Biotechnology ”

Nguyễn Thị Hoài Thu, N. Quynh, Dang Nguyen Tuong Van, Luu Tran Thanh Uyen, Thien‐Hoang Ho, Lê Thành Long, Chi Nguyen Quynh Ho, To Minh Quan

TLDR Astaxanthin may help protect hair cells from damage and prevent hair loss.

This study evaluated the protective effects of astaxanthin (ASX), a potent antioxidant, on human dermal papillae (hDP) cells against oxidative stress induced by hydrogen peroxide (H2O2), a factor contributing to hair loss. The hDP cells were isolated and treated with ASX before exposure to H2O2. Results showed a significant reduction in oxidative stress markers, with b-galactosidase expression decreasing from 87% in the control group to 27.61% in the ASX-treated group. These findings suggest that ASX effectively protects hDP cells from oxidative damage, indicating its potential use in treating hair loss related to reactive oxygen species.

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