Application of Stem Cells in Regenerative Medicine

June 2023 in “ MedComm ”

Ye Jin, Shuangyang Li, Yu Q, Tianli Chen, Da Liu

Studysummary This study summarizes the role and potential applications of stem cell exosomes in skin and bone healing, highlighting their regenerative capabilities and suggesting innovative delivery methods like nanoliposomes and hydrogels to improve bioavailability and therapeutic outcomes.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document discusses the role of stem cells and their exosomes in regenerative medicine, particularly in skin and bone healing. Stem cells can self-replicate, differentiate, and modulate the immune system, aiding in tissue regeneration and chronic wound treatment. Stem cell exosomes share similar properties and play a crucial role in tissue regeneration and wound healing. The paper proposes the use of nanoformulations, liposomes, nanoliposomes, polymer micelles, microspheres, hydrogels, and scaffold microneedles to improve their delivery. The document also highlights the anti-inflammatory and immunomodulatory effects of mesenchymal stem cells (MSCs), which are crucial in the wound healing process. MSCs can migrate to the site of injury and differentiate into local components, aiding in tissue regeneration. The document also discusses the role of stem cells in nerve regeneration and hair follicle regeneration. The document also discusses the application of stem cells in regenerative medicine, focusing on their use in bone regeneration and skin regeneration through exosomes. The document also discusses the potential of combining stem cells and exosomes with nanotechnology for more precise and effective treatment. The document discusses the application of various nanoformulations in stem cell therapy and drug delivery. The document concludes that targeted transport of stem cells using these methods can effectively repair lesion sites and maintain stem cells. However, there are still many unanswered research questions, such as how to accurately track the growth of stem cells in the body, the number of cells needed for treatment, and whether stem cells remain in the lungs after whole-body transplantation.

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Research cited in this study

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research Application of Stem Cells in Regenerative Medicine

3 citations , June 2023 in “MedComm”

This study summarizes the role and potential applications of stem cell exosomes in skin and bone healing, highlighting their regenerative capabilities and suggesting innovative delivery methods like nanoliposomes and hydrogels to improve bioavailability and therapeutic outcomes.

research A Combination Therapy for Androgenic Alopecia Based on Quercetin and Zinc/Copper Dual-Doped Mesoporous Silica Nanocomposite Microneedle Patch

1 citations , December 2022 in “Bioactive Materials”

In this study, researchers developed a nanocomposite microneedle patch containing copper/zinc dual-doped silica nanoparticles, which release substances to promote hair follicle regeneration by targeting various pathophysiological aspects of androgenic alopecia, presenting an effective anti-hair loss treatment strategy.

research The Efficacy of LED Microneedle Patch on Hair Growth in Mice

14 citations , November 2022 in “Archives of Dermatological Research”

This study found that a green-light LED microneedle patch enhanced hair growth in mice with the best results among tested wavelengths, showing increased hair follicles and no serious side effects, suggesting its potential for treating androgenetic alopecia.

research Conditioned Media-Integrated Microneedles for Hair Regeneration Through Perifollicular Angiogenesis

12 citations , August 2022 in “Journal of Controlled Release”

In this study, a microneedle patch containing conditioned media from hypoxia-pretreated stem cells enhanced hair regeneration in an androgenetic alopecia mouse model by boosting perifollicular vascularization and hair follicle stem cell activation compared to minoxidil.

research A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy

31 citations , July 2022 in “Advanced healthcare materials/Advanced Healthcare Materials”

In this study, researchers developed a drug-free microneedle patch using chitosan lactate and stem cell-derived exosomes that significantly promotes hair regeneration in animal tests compared to minoxidil, highlighting its potential as a simple and efficient hair loss treatment.

research Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation

76 citations , February 2021 in “International Journal of Molecular Sciences”

This review examines how mesenchymal stem cells and their derivatives may enhance skin regeneration and rejuvenation, but it reports no new clinical results; the authors suggest iPSC-derived MSCs hold promise for future therapies.

research Current Advances in Stem Cell-Based Therapies for Hair Regeneration

32 citations , May 2020 in “European Journal of Pharmacology”

This review discusses the potential of stem cell-based therapies, particularly involving stem cell-derived conditioned medium and exosomes, for hair regeneration in nonscarring alopecia, but it reports no new clinical outcomes.

research Hair Follicle Stem Cells Differentiation Into Bone Cells on Collagen Scaffold

17 citations , February 2020 in “Cell and Tissue Banking”

research A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

192 citations , April 2019 in “ACS nano”

In a mouse model, this study demonstrated that a microneedle patch system using keratin and integrated with MSC-derived exosomes and UK5099 promoted hair regrowth more efficiently than traditional delivery methods.

research Are Hair Follicle Stem Cells Promising Candidates for Wound Healing?

18 citations , December 2018 in “Expert Opinion on Biological Therapy”

This review discusses hair follicle stem cells for wound healing and reports no new clinical results, noting their potential but emphasizing the need for further understanding and safety in clinical applications.

research Is Skin Microneedling a Good Alternative Method for Various Skin Defects Removal

23 citations , September 2018 in “Dermatologic Therapy”

This article explains that skin microneedling promotes skin regeneration by creating microinjuries, which stimulate collagen and elastin production, making it effective for treating various skin issues with high effectiveness, limited side effects, and a short recovery time.

research Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids

169 citations , January 2018 in “Cell Reports”

In this study, researchers successfully derived skin organoids from mouse pluripotent stem cells that spontaneously produce hair follicles, potentially aiding in hair growth research and in vitro drug testing.

research Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells

55 citations , May 2017 in “Current stem cell research & therapy”

In this study, Japanese patients treated with adipose-derived stem cell-conditioned medium for hair regeneration showed positive outcomes, suggesting it may be an effective new therapy for alopecia.

research Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF

117 citations , March 2017 in “Nature Communications”

This study shows that macrophage-induced TNF signaling can activate hair follicle stem cells and promote new hair follicle formation after wounding by regulating AKT/β-catenin pathways.

research Wound Healing and Skin Regeneration

359 citations , January 2015 in “Cold Spring Harbor Perspectives in Medicine”

This article reviews the role of skin appendages in wound healing and appendage regeneration, discussing cellular and molecular mechanisms but reports no new experimental findings.

research Prospect of Stem Cell Conditioned Medium in Regenerative Medicine

298 citations , January 2014 in “BioMed Research International”

This review discusses various methods for obtaining stem cell-derived conditioned media and its applications in disease treatment, finding generally positive results but highlighting the need for standardized production methods.

Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

research Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

74 citations , January 2013 in “Expert Opinion on Biological Therapy”

This review discusses recent advances in hair follicle biology, regeneration, and tissue engineering, highlighting emerging therapeutic opportunities, and reports no new experimental results.

research Therapeutic Potential of Stem Cells in Skin Repair and Regeneration

73 citations , August 2008 in “Chinese Journal of Traumatology”

This review outlines recent advances in using stem cells for skin repair and regeneration, suggesting potential for complete skin and appendage regeneration after severe burns, but presents no new clinical findings.