Comparative Efficacy of JAK Inhibitors in Acute Versus Nonacute Alopecia Areata: A Retrospective Cohort Study

    May 2026 in “ Acta Dermato Venereologica ”
    Ruxin Ji, Man Zhang, Tian Tian … Yan Tang
    Studysummary This study observed that patients with acute alopecia areata treated with Janus kinase inhibitors achieved a higher rate of complete hair regrowth by week 24 compared to those with non-acute disease, highlighting the benefits of early intervention.
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    Research cited in this study 15

    1. Characteristics And Predictive Values Of Super-Responders In Alopecia Areata Under Tofacitinib Treatment: A Single-Center Retrospective Study Clinical and Experimental Dermatology · 2025
    2. Patterns of Clinical Response in Patients With Alopecia Areata Treated With Ritlecitinib in the Allegro Clinical Development Programme Journal of the European Academy of Dermatology and Venereology · 2025
    3. Predictors And Management Of Inadequate Response To JAK Inhibitors In Alopecia Areata American Journal of Clinical Dermatology · 2024
    4. Novel Investigational Drugs for Alopecia Areata and Future Perspectives Expert opinion on investigational drugs · 2024
    5. Comparative Efficacy and Safety of JAK Inhibitors in the Treatment of Moderate-to-Severe Alopecia Areata: A Systematic Review and Network Meta-Analysis Frontiers in pharmacology · 2024
    6. Comparative Efficacy of Oral Janus Kinase Inhibitors and Biologics in Adult Alopecia Areata: A Systematic Review and Bayesian Network Meta-Analysis Journal of the European Academy of Dermatology and Venereology · 2024
    7. European Expert Consensus Statement on the Systemic Treatment of Alopecia Areata JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    8. The New Era of JAK Inhibitors: Impelling Updates in Alopecia Areata Guideline Journal of the European Academy of Dermatology and Venereology · 2023
    9. Effectiveness and Predictive Factors of Response to Tofacitinib Therapy in 125 Patients with Alopecia Areata: A Single-Centre Real-World Retrospective Study Acta dermato-venereologica · 2023
    10. Expecting Scalp Hair Regrowth During Severe Alopecia Areata Treatment with Baricitinib: Insights from Patient Trajectories in Phase III Trials British Journal of Dermatology · 2023
    11. Guidelines for the Management of Patients with Alopecia Areata in Korea: Part II Systemic Treatment Annals of Dermatology · 2023
    12. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    13. The Alopecia Areata Investigator Global Assessment Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials British Journal of Dermatology · 2020
    14. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    15. Multivariate Analysis of Prognostic Factors in Patients With Rapidly Progressive Alopecia Areata Journal of The American Academy of Dermatology · 2012