Characteristics And Predictive Values Of Super-Responders In Alopecia Areata Under Tofacitinib Treatment: A Single-Center Retrospective Study

This study analyzed 80 alopecia areata (AA) patients treated with tofacitinib to identify super-responders (SRs), who show rapid hair regrowth. SRs were defined as those achieving a ≥80% reduction in the Severity of Alopecia Tool (SALT) score by 3 months or a 100% reduction by 6 months. The study found that 37.5% of patients were SRs, with significant predictors including older age and no prior JAK inhibitor treatment. Female patients and those without previous corticosteroid use also showed higher SR rates, though not statistically significant. SRs experienced faster and more sustained hair regrowth, with 93.3% achieving SALT100 by 6 months, compared to 42% of non-super-responders at 12 months. The findings suggest that early identification of SRs can improve treatment strategies and patient outcomes, though further research is needed to confirm these results in larger, multicenter studies.