MLPH-Mediated Activation of Dermal Papilla IGF-1 Signaling Drives Human Hair Shaft Elongation and Anagen Induction

    February 2026 in “ Biomedicine & Pharmacotherapy ”
    Mi Hee Kwack, Eunho Kang, Jewoo Kim … Cheil Moon
    Studysummary In this study, researchers developed EPO-derived peptides that enhanced hair growth by stimulating dermal papilla cells and increasing IGF-1 expression without triggering systemic erythropoietic effects in tested models, indicating a promising approach for treating hair loss.
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    Research cited in this study 14

    1. Androgenetic Alopecia: A Review Nigerian Postgraduate Medical Journal · 2024
    2. Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia Journal of Dermatological Treatment · 2022
    3. Lifestyle Factors Involved in the Pathogenesis of Alopecia Areata International journal of molecular sciences · 2022
    4. Common Causes of Hair Loss: Clinical Manifestations, Trichoscopy, and Therapy Journal of the European Academy of Dermatology and Venereology · 2020
    5. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    6. Novel Drug Delivery Approaches for the Management of Hair Loss Expert opinion on drug delivery · 2020
    7. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    8. The Medical and Psychosocial Associations of Alopecia: Recognizing Hair Loss as More Than a Cosmetic Concern American Journal of Clinical Dermatology · 2018
    9. Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth International Journal of Cosmetic Science · 2018
    10. Establishment and Characterization of Five Immortalized Human Scalp Dermal Papilla Cell Lines Biochemical and Biophysical Research Communications · 2018
    11. Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle Biological Reviews · 2014
    12. Erythropoietin Induces Insulin-Like Growth Factor-1 from Three-Dimensional Culture of Human Dermal Papilla Cells Journal of Dermatological Science · 2012
    13. Erythropoietin Promotes Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice Journal of Dermatological Science · 2010
    14. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995