Safety of Low-Dose Oral Minoxidil Treatment for Hair Loss: A Systematic Review and Pooled Analysis of Individual Patient Data

    August 2020 in “ Dermatologic Therapy ”
    Juan Jimenez-Cauhe, David Saceda-Corralo, Rita Rodrigues‐Barata … Sergio Vano-Galvan
    Studysummary This study reported that low-dose oral minoxidil is generally safe for treating various types of hair loss, though it may cause hypertrichosis and pedal edema, especially at higher doses.
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    Research cited in this study 15

    1. Low-Dose Oral Minoxidil for Female Pattern Hair Loss: A Unicenter Descriptive Study of 148 Women Skin appendage disorders · 2020
    2. Very-Low-Dose Oral Minoxidil in Male Androgenetic Alopecia: A Study with Quantitative Trichoscopic Documentation Journal of The American Academy of Dermatology · 2019
    3. Combination Tofacitinib and Oral Minoxidil Treatment for Severe Alopecia Areata Journal of The American Academy of Dermatology · 2019
    4. Minoxidil 1 mg Oral Versus Minoxidil 5% Topical Solution for the Treatment of Female-Pattern Hair Loss: A Randomized Clinical Trial Journal of The American Academy of Dermatology · 2019
    5. Oral Minoxidil Bio-Activation by Hair Follicle Outer Root Sheath Cell Sulfotransferase Enzymes Predicts Clinical Efficacy in Female Pattern Hair Loss Journal of The European Academy of Dermatology and Venereology · 2019
    6. Effectiveness and Safety of Low-Dose Oral Minoxidil in Male Androgenetic Alopecia Journal of The American Academy of Dermatology · 2019
    7. Case Series of Oral Minoxidil for Androgenetic and Traction Alopecia: Tolerability and the Five C’s of Oral Therapy Dermatologic Therapy · 2018
    8. Loose Anagen Hair Syndrome: Treatment with Systemic Minoxidil Characterized by Marked Hair Color Change Australasian Journal of Dermatology · 2018
    9. Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone International Journal of Dermatology · 2017
    10. Treatment of Chronic Telogen Effluvium with Oral Minoxidil: A Retrospective Study F1000Research · 2017
    11. Familial Frontal Fibrosing Alopecia Treated With Dutasteride, Minoxidil, and Artificial Hair Transplantation Australasian Journal of Dermatology · 2016
    12. Treatment of Monilethrix with Oral Minoxidil JAAD case reports · 2016
    13. Treatment of Permanent Chemotherapy-Induced Alopecia with Low Dose Oral Minoxidil Australasian Journal of Dermatology · 2015
    14. Efficacy and Safety of Oral Minoxidil 5 mg Daily During 24-Week Treatment in Male Androgenetic Alopecia Journal of The American Academy of Dermatology · 2015
    15. The Pharmacokinetics of 2.5- to 10-mg Oral Doses of Minoxidil in Healthy Volunteers The Journal of Clinical Pharmacology · 1989

    Related research 10

    1. Ethnopharmacological Review of Medicinal Plants for the Treatment of Alopecia International Journal of Advanced Research in Science, Communication and Technology · 2023
    2. What's New in Therapy for Male Androgenetic Alopecia? American Journal of Clinical Dermatology · 2022
    3. Systemic Minoxidil for Hair Disorders in Pediatric Patients: A Safety and Tolerability Review International Journal of Dermatology · 2022
    4. Role of Low Dose Oral Minoxidil in the Treatment of Hair Loss: A Review Cosmoderma · 2021
    5. Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients Journal of The American Academy of Dermatology · 2021
    6. A Case of Contact Allergic Dermatitis to Topical Minoxidil Cureus · 2021
    7. Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment Dermatology and therapy · 2020
    8. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    9. Infantile Generalized Hypertrichosis Caused by Topical Minoxidil Anais Brasileiros de Dermatologia · 2016
    10. Topical Minoxidil for Hair Growth in Alopecia Areata and Androgenetica Drugs · 1987