Delayed Epidermal Permeability Barrier Formation and Hair Follicle Aberrations in Inv-Cldn6 Mice

    April 2005 in “ Mechanisms of development ”
    Tammy-Claire Troy, Ramtin Rahbar, Azadeh Arabzadeh … Kursad Turksen
    Studysummary This study found that heterozygous mice overexpressing Claudin-6 experienced alterations in epidermal and hair follicle differentiation, leading to distinctive coat characteristics and a disrupted epidermal permeability barrier.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 14

    1. Overexpression Of Sonic Hedgehog Suppresses Embryonic Hair Follicle Morphogenesis Developmental Biology · 2003
    2. Molecular Biology of Hair Morphogenesis: Development and Cycling Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution · 2003
    3. Overexpression of the Calcium Sensing Receptor Accelerates Epidermal Differentiation and Permeability Barrier Formation In Vivo Mechanisms of Development · 2003
    4. Epithelial Barrier Function: Assembly and Structural Features of the Cornified Cell Envelope BioEssays · 2002
    5. Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: Annotated Tables Experimental dermatology · 2001
    6. Genetically Separable Determinants of Hair Keratin Gene Expression Developmental Dynamics · 2000
    7. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development The Journal of Cell Biology · 1998
    8. The Epidermis: Rising to the Surface Current opinion in genetics & development · 1994
    9. Sequence and Expression of Murine Type I Hair Keratins mHa2 and mHa3 Experimental Cell Research · 1994
    10. Interleukin 6: Insights Into Its Function in Skin by Overexpression in Transgenic Mice Proceedings of the National Academy of Sciences · 1992
    11. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989
    12. Expression of Hair-Related Keratins in a Soft Epithelium: Subpopulations of Human and Mouse Dorsal Tongue Keratinocytes Express Keratin Markers for Hair, Skin, and Esophageal Types of Differentiation Experimental Cell Research · 1989
    13. Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986
    14. Growth of the Hair Physiological Reviews · 1954