Spatiotemporal Immunomodulation by Engineered Hair Follicle Stem Cell-Derived Nanovesicles Enables Scarless Regeneration of Infected Wounds

January 2026 in “ Chemical Engineering Journal ”

Yiwen Yang, Qinzhen Cheng, Yi Hu, Yijing Zhang, Nana Ran, Jinmei Yang, Tianze Du, Li Wang, Yong Kang, Mingjie Kuang, S Zhang, Xiaoyuan Ji

hair follicle stem cell-derived nanovesicles fM-HFNVs@CG scarless regeneration immunomodulation neutrophil recruitment pathogen elimination inflammation regulation Treg differentiation M2 macrophage polarization fibroblast bioenergetics collagen alignment hair follicle density

Studysummary In this study, researchers developed a programmable system using engineered nanovesicles from hair follicle stem cells to modulate immune responses, which showed promise in precisely controlling inflammation, promoting immune balance, and accelerating wound healing, particularly for infected wounds.

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Spatiotemporal Immunomodulation by Engineered Hair Follicle Stem Cell-Derived Nanovesicles Enables Scarless Regeneration of Infected Wounds

Research cited in this study

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