Crosstalk Between Endothelial Cells and Dermal Papilla Entails Hair Regeneration and Angiogenesis During Aging

May 2024 in “ Journal of Advanced Research ”

Siyi Zhou, Zeming Li, Xinzhu Li, Y. Ye, Mengyue Wang, Jingwei Jiang, Tao Lei, Yan Wei, Ching‐Chieh Tung, Yongji Chung, Eun‐Mi Kim, Xinyu Shen, Xue‐Gang Xu, Xiao Juan Xiang, Qiaoli Xie, Jinwei Zhang, Wang Wu, Xia Lin, Cheng Ming Chuong, Mingxing Lei

Studysummary In this study, researchers found that the interaction between dermal papilla and endothelial cells decreases with age, affecting signaling pathways that promote hair regeneration and angiogenesis in mouse models.

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The study investigates the interactions between endothelial cells (ECs) and dermal papilla (DP) cells in hair regeneration and angiogenesis during aging. It reveals that these interactions decrease with age, leading to impaired hair regeneration and angiogenesis. Key signaling pathways, such as EDN1-EDNRA and CTF1-IL6ST, are crucial for these processes, with EDN1-EDNRA promoting taurine metabolism and hair regeneration, and CTF1-IL6ST enhancing alpha-linolenic acid metabolism and angiogenesis. The findings, supported by various experimental models including single-cell RNA sequencing and mouse organoid cultures, highlight the mutualistic relationship between hair follicles and blood vessels and suggest potential therapeutic targets for age-related hair loss.

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