Inflammation, Stem Cells and Wound Healing in Skin Aging

    October 2022 in “ Frontiers in Cell and Developmental Biology ”
    Mingxing Lei, Wen-Hui Lien, Ji Li
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    TLDR Aging skin is affected by inflammation, reduced stem cell function, and slower wound healing.
    The document discusses the complex process of skin aging, which is influenced by factors such as UV-light exposure, cellular senescence, genetic mutations, and decreased hormone levels. It highlights the role of inflammation, stem cell activity, and wound healing in skin aging. Chronic inflammation can induce skin cell senescence and compromise stem cell activity and wound responses. The document also discusses the role of heat shock protein 27 (HSP27) in protecting against UV-induced skin photoaging, and the changes in the dermal extracellular matrix (ECM) with skin aging. It further explores the relationship between type 2 inflammation and skin immunosenescence, and the dysregulation of invariant natural killer T (iNKT) cells in the pathogenesis of psoriasis. The decrease in the number and activity of stem cells during skin aging leads to age-related alopecia and delayed wound healing. The document concludes by emphasizing the need for further research to understand the mechanisms of aging-related skin inflammatory diseases, hair regeneration, and wound healing.
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