Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology

    February 2026 in “ American Journal of Clinical Dermatology ”
    Olivia M. Burke, Sophie M. Bilik, Caroline Dodson … R. Stone
    Studysummary This source discusses how radiotherapy-induced skin fibrosis, a chronic side effect affecting cancer survivors' quality of life, is driven by ongoing inflammation and fibroblast activity, and emphasizes the need for comprehensive dermatologic management and better diagnostic tools.
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    Research cited in this study 8

    1. Microneedle Radiofrequency Induces Extracellular Matrix Remodeling Through Fibroblast Activation: A Histological Study in a Porcine Model Lasers in Surgery and Medicine · 2025
    2. Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis International journal of molecular sciences · 2024
    3. Clinical Pathobiology of Radiotherapy-Induced Alopecia: A Guide Toward More Effective Prevention and Hair Follicle Repair ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    4. Single-Cell Transcriptomics Reveals a Senescence-Associated IL-6/CCR6 Axis Driving Radiodermatitis EMBO molecular medicine · 2022
    5. Radiofrequency Microneedling: A Comprehensive and Critical Review Dermatologic Surgery · 2021
    6. Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy Cancer Research · 2017
    7. A Simple Assay for the Study of Human Hair Follicle Damage Induced by Ionizing Irradiation Experimental dermatology · 2009
    8. Permanent Alopecia After Cranial Irradiation: Dose–Response Relationship International journal of radiation oncology, biology, physics · 2004