Clinical, Mechanistic, and Therapeutic Landscape of Cutaneous Fibrosis

    September 2024 in “ Science Translational Medicine ”
    Dayan J. Li, Charlotte E. Berry, Derrick C. Wan, Michael T. Longaker
    Studysummary This study provides a comprehensive framework for understanding, managing, and addressing skin fibrosis, highlighting common pathways and new therapeutic opportunities for various fibrosis-related disorders that currently lack effective treatments.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 12

    1. Profibrotic Subsets of SPP1+ Macrophages and POSTN+ Fibroblasts Contribute to Fibrotic Scarring in Acne Keloidalis Journal of Investigative Dermatology · 2024
    2. Ritlecitinib And Brepocitinib Demonstrate Significant Improvement In Scalp Alopecia Areata Biomarkers ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2021
    3. Fibroblasts: Origins, Definitions, and Functions in Health and Disease Cell · 2021
    4. A Review of the Evidence for and Against a Role for Mast Cells in Cutaneous Scarring and Fibrosis International Journal of Molecular Sciences · 2020
    5. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    6. Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair Cell Stem Cell · 2020
    7. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin Journal of Investigative Dermatology · 2018
    8. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    9. Fibromodulin Reduces Scar Formation in Adult Cutaneous Wounds by Eliciting a Fetal-Like Phenotype Signal Transduction and Targeted Therapy · 2017
    10. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    11. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    12. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013