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Dynamic Changes in Fibroblast Subpopulations Drive Development of Radiation-Induced Skin Fibrosis Through the Fra/c-Jun Pathway

research 1493 Dynamic changes in fibroblast subpopulations drives development of radiation-induced skin fibrosis through the fra/c-jun pathway

April 2023 in “Journal of Investigative Dermatology”

In this study, researchers discovered that fat grafting helps reduce dermal fibrosis in radiation-injured mouse skin by decreasing specific fibroblast subpopulations associated with Fra/c-Jun signaling.

research Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology

February 2026 in “American Journal of Clinical Dermatology”

This source discusses how radiotherapy-induced skin fibrosis, a chronic side effect affecting cancer survivors' quality of life, is driven by ongoing inflammation and fibroblast activity, and emphasizes the need for comprehensive dermatologic management and better diagnostic tools.

research Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury

19 citations , February 2017 in “Journal of radiation research”

This study found that high-dose radiation can induce accelerated cellular senescence, inflammation, and loss of epithelial stem cells in mouse and human skin, contributing to radiation dermatitis.

research Skin Toxicity in Palliative Radiation Therapy

January 2017 in “Elsevier eBooks”

This article reviews skin toxicities caused by radiation in metastatic cancer patients and discusses preventive measures, highlighting that current interventions lack robust supporting data.

research Clinical Role of Oral Vitamin C and E Therapy in Skin and Hair Disorders

June 2021 in “International journal of cosmetics and dermatology”

This review found limited support for oral vitamin C and E in treating pigmentary disorders like chloasma, inflammatory conditions, and pressure wounds, with evidence constrained by small, varied studies.

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Community Join

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community South Korean Red Light Therapy Study

41 upvotes 6 months ago

Korean scientists developed a red light therapy that reduces a hair loss marker by 92%. Users discussed the benefits and drawbacks of natural sunlight versus red light caps for hair health, with some suggesting supplements for vitamin D.

community Most Underrated Hack for Hair Loss is Water

in Chat 68 upvotes 8 months ago

Filtered shower heads may improve scalp and hair health but do not affect male pattern baldness (MPB). Genetics and factors like DHT and scalp tension are more significant in hair loss.

community I think I’ve finally found the reason for my hair loss

in Chat 98 upvotes 1 year ago

The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

140 upvotes 11 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community The Health Benefits of Head Hair

in Research/Science 19 upvotes 11 months ago

Hair provides protection against head trauma, reduces skin cancer risk, helps remove heavy metals, and aids in wound healing. The conversation emphasizes the health benefits of maintaining head hair beyond cosmetic reasons.

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Noelle Skin
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Noelle Skin