Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells

April 2018 in “ Biochemical and Biophysical Research Communications ”

Lijuan Zhou, Han Wang, Jing Jing, Lijuan Yu, Xianjie Wu, Lu Zhang

exosomes dermal papilla cells DPC-Exos hair follicle growth anagen phase catagen phase outer root sheath cells ß-catenin Sonic hedgehog growth phase regression phase beta-catenin Shh

Studysummary In this study, dermal papilla cell-derived exosomes accelerated hair follicle growth in mice, suggesting potential for treating hair loss by modulating key signaling pathways.

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In the 2018 study, researchers found that exosomes derived from dermal papilla cells (DPC-Exos) could promote hair follicle growth and development in mice. Injecting DPC-Exos into mice led to an accelerated transition into the anagen phase and a delayed transition into the catagen phase, resulting in longer hair shafts and larger hair bulb diameters. In vitro, DPC-Exos enhanced the proliferation and migration of outer root sheath cells and increased the expression of key signaling molecules like ß-catenin and Sonic hedgehog. These findings suggest that DPC-Exos could be a potential treatment for hair loss. The study used human scalp specimens from 15 individuals for cell isolation and included in vivo experiments on mice, although the exact number of mice used was not specified.

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