Relation of Urinary Stone Disease with Androgenetic Alopecia and Serum Testosterone Levels

May 2016 in “ Urolithiasis ”

Emre Can Polat, Levent Ozcan, Alper Otunctemur, Emin Ozbek

androgenetic alopecia serum testosterone testosterone deficiency urolithiasis vertex pattern alopecia total alopecia renal osteopontin androgens prostate cancer insulin resistance AGA testosterone kidney stones balding hair loss osteopontin

Studysummary This study found that the risk of urinary stone disease increased significantly in patients with severe androgenetic alopecia, and that testosterone deficiency was more frequent among these patients.

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Research cited in this study

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research The Association of Urolithiasis and Androgenetic Alopecia

1 citations , October 2015 in “Renal Failure”

This study observed a significant correlation between vertex pattern and total alopecia and the presence of urinary stones in patients under 60 years old.

research Androgenetic Alopecia and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis

34 citations , February 2013 in “Journal of The American Academy of Dermatology”

This meta-analysis found that vertex pattern androgenetic alopecia was associated with an increased risk of developing prostate cancer, while other androgenetic alopecia patterns did not show a significant link.

research The Role of Androgen and Androgen Receptor in Skin-Related Disorders

124 citations , July 2012 in “Archives of Dermatological Research”

This review discusses the roles of androgens and androgen receptors in skin-related disorders and suggests that targeting androgen receptors may be a more effective treatment strategy.

research Androgenetic Alopecia as an Early Marker of Benign Prostatic Hyperplasia

28 citations , August 2011 in “Journal of The American Academy of Dermatology”

This study found that men with early-onset androgenetic alopecia had significantly larger prostate volumes and lower urinary flow rates compared to healthy controls, suggesting a possible link between AGA and prostate-related urinary symptoms.

research Baldness, Acne, and Testicular Germ Cell Tumors

31 citations , December 2010 in “International Journal of Andrology”

This study found that male pattern baldness and a history of severe acne were inversely associated with testicular germ cell tumors, while taller height showed a positive association.

research Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla

122 citations , November 2010 in “Journal of Dermatological Science”

This study found that increased expression of type II 5α-reductase, androgen receptors, and Hic-5/ARA55 in dermal papilla cells upregulates androgen sensitivity, playing a key role in androgenetic alopecia pathogenesis.

research Androgenetic Alopecia and Cardiovascular Risk Factors in Men and Women: A Comparative Study

110 citations , July 2010 in “Journal of The American Academy of Dermatology”

Hair loss linked to higher heart disease risk in both men and women.

research Is Androgenetic Alopecia a Risk for Atherosclerosis?

38 citations , February 2009 in “Journal of The European Academy of Dermatology and Venereology”

This study found that patients with severe vertex pattern androgenetic alopecia had significantly higher carotid intima-media thickness, suggesting an increased risk of subclinical atherosclerosis compared to other alopecia patterns and healthy controls.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , June 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research Patients With a Large Prostate Show a Higher Prevalence of Androgenetic Alopecia

33 citations , October 2004 in “Archives of Dermatological Research”

This study suggests that a larger prostate is associated with a higher prevalence of androgenetic alopecia, although the prostate size did not correlate with alopecia severity.

research What May Be the Markers of the Male Equivalent of Polycystic Ovary Syndrome?

39 citations , January 2004 in “Physiological Research”

In this study, researchers reported that about one-third of men with premature alopecia displayed hormonal shifts and higher insulin resistance, resembling the prevalence pattern of PCOS in women.

research Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors

155 citations , December 2003 in “British Journal of Dermatology”

In this study, the researchers did not confirm previously reported links between AGA and smoking or benign prostatic hypertrophy, but found potential associations with alcohol consumption and lean body mass at age 21 that merit further investigation.

research Hair Loss, Insulin Resistance, and Heredity in Middle-Aged Women: A Population-Based Study

49 citations , June 2003 in “European journal of cardiovascular prevention & rehabilitation”

In this study, female androgenic alopecia (grade II or III on Ludwig's scale) was found to be common among Finnish women aged 63, and several markers of insulin resistance, along with paternal history of alopecia, were associated with an increased risk.

research Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness

299 citations , March 2001 in “Journal of Investigative Dermatology”

This study found that specific genetic markers near the androgen receptor gene are significantly more common in men with male pattern baldness, suggesting a genetic component in its development.

research Early Androgenetic Alopecia as a Marker of Insulin Resistance

115 citations , September 2000 in “The Lancet”

Early hair loss may indicate risk of insulin resistance.

research Association of Benign Prostatic Hyperplasia with Male Pattern Baldness

54 citations , May 1998 in “Urology”

This study demonstrates that patients with benign prostatic hyperplasia have a higher severity and frequency of male pattern baldness compared to a control group.

research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp

227 citations , January 1998 in “Journal of Endocrinology”

This study found that dermal papilla cells from balding scalp hair follicles have significantly higher levels of androgen receptors than those from non-balding follicles, supporting their in vivo androgen response.

research Effect of Castration and Finasteride on Urinary Oxalate Excretion in Male Rats

23 citations , January 1998 in “Urological research”

Castration and finasteride lower urinary oxalate in male rats, potentially treating urolithiasis.