Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, P2Y5/LPA6

April 2009 in “ Journal of Biological Chemistry ”

K. Yanagida, Kayo Masago, Hiroki Nakanishi, Yasuyuki Kihara, Fumie Hamano, Yoko Tajima, Ryo Taguchi, Takao Shimizu, Satoshi Ishii

lysophosphatidic acid LPA p2y5 LPA6 G13-Rho signaling pathway 2-acyl-LPA 1-acyl-LPA small interfering RNA Rho-dependent changes LPA receptor-null hair growth siRNA

Studysummary This study found that p2y5 functions as a novel LPA receptor involved in the G13-Rho signaling pathway, with implications for human hair growth, and proposes renaming it to LPA6.

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The study identified p2y5 as a novel lysophosphatidic acid (LPA) receptor, designated LPA6, which was involved in the G12/13-Rho signaling pathways and influenced cellular morphology and cAMP accumulation. It was particularly responsive to 2-acyl-LPA and played a role in human hair growth, with genetic defects in p2y5 linked to hair growth deficiencies. The research used various assays and cell lines to confirm p2y5's function as an LPA receptor, highlighting its potential as a target for hair-related conditions. The findings extended the understanding of LPA's functional roles and receptor interactions, suggesting p2y5's involvement in specific cellular morphological changes and its impact on hair follicle development.

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research Disruption of P2RY5, an Orphan G Protein–Coupled Receptor, Underlies Autosomal Recessive Woolly Hair

210 citations , February 2008 in “Nature genetics”

This study found mutations in the P2RY5 gene that are linked to autosomal recessive woolly hair in Pakistani families, implicating it in hair texture determination.

research Human Hair Growth Deficiency Is Linked to a Genetic Defect in the Phospholipase Gene LIPH

194 citations , November 2006 in “Science”

This study identified a gene mutation in the LIPH gene associated with inherited hair loss and hair growth defects in certain populations, suggesting lipase H plays a role in hair development.