TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling

    August 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Luyang Xiong, Irina Zhevlakova, Xiaoxia Z. West … Tatiana V. Byzova

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that TLR2 is crucial for maintaining hair follicle health and regeneration, and its stimulation by the metabolite CEP may promote hair growth, while decreases in TLR2 and CEP in aging and obesity may hinder hair growth.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on biorxiv.org →
    Discuss this study in the Community →

    Research cited in this study 17

    1. Timely Wound Healing Is Dependent on Endothelial but Not on Hair Follicle Stem Cell Toll-Like Receptor 2 Signaling Journal of Investigative Dermatology · 2022
    2. Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence Nature · 2021
    3. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    4. Immune Modulation of Hair Follicle Regeneration npj Regenerative Medicine · 2020
    5. Injury Modifies the Fate of Hair Follicle Dermal Stem Cell Progeny in a Hair Cycle-Dependent Manner Experimental dermatology · 2019
    6. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    7. Role of Arachidonic Acid in Promoting Hair Growth Annals of dermatology/Annals of Dermatology · 2016
    8. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    9. Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations Cell · 2015
    10. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    11. Androgenetic Alopecia, Metabolic Syndrome, and Insulin Resistance: Is There Any Association? A Case-Control Study Indian Dermatology Online Journal · 2014
    12. Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation Proceedings of the National Academy of Sciences · 2013
    13. Age-Associated Inflammation Inhibits Epidermal Stem Cell Function Genes & development · 2012
    14. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    15. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    16. Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin The FASEB Journal · 2001
    17. Alopecia in Crash Dieters PubMed · 1976

    Related research 1

    1. TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling bioRxiv (Cold Spring Harbor Laboratory) · 2023