Biocomposite Nanofiber Matrices to Support ECM Remodeling by Human Dermal Progenitors and Enhanced Wound Closure

    August 2017 in “ Scientific Reports ”
    Fraz Anjum, Natacha A. Agabalyan, Holly D. Sparks … Jeff Biernaskie
    Studysummary This study found that PCL-based nanofiber scaffolds enhanced cell proliferation and extracellular matrix deposition, suggesting they show promise as a cell delivery system for improving skin wound healing.
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    Research cited in this study 8

    1. Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal npj Regenerative Medicine · 2017
    2. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    3. Principles and Mechanisms of Regeneration in the Mouse Model for Wound-Induced Hair Follicle Neogenesis Regeneration · 2015
    4. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    5. Epidermal Stem Cells: An Update on Their Potential in Regenerative Medicine Expert opinion on biological therapy · 2013
    6. SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells Cell stem cell · 2009
    7. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    8. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005