The Application of Local Hypobaric Pressure: A Novel Means to Enhance Macromolecule Entry Into the Skin

    January 2016 in “ Journal of Controlled Release ”
    Ricardo Inacio, Simon P. Poland, Xudong Cai … Stuart A. Jones
    Studysummary This study found that applying controlled hypobaric stress to the skin significantly improved the in vitro and in vivo penetration of macromolecules, facilitating enhanced drug delivery.
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    Research cited in this study 2

    1. Analysis of Hair Follicle Penetration of Lidocaine and Fluorescein Isothiocyanate-Dextran 4 kDa Using Hair Follicle-Plugging Method Drug Development and Industrial Pharmacy · 2013
    2. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011