Microinfusion of Medications Into the Skin as a Drug Delivery Technique: A Narrative Review

    November 2025 in “ Dermatology Reports ”
    Khalid Nabil Nagshabandi, Raed Alojayri, Abdulaziz Alghufaili, Mona Alkallabi
    Studysummary This review found that microinfusion of medications using tattoo devices (MMP®) shows potential as a minimally invasive method for treating ailments like alopecia and basal cell carcinoma, offering notable improvements with minimal side effects due to localized drug delivery.
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    Research cited in this study 9

    1. Dutasteride Infusion in Male Androgenetic Alopecia Using a Novel Drug Delivery Technique: MMP Skin Appendage Disorders · 2025
    2. Split-Scalp Pilot Study to Evaluate Effectiveness of Minoxidil 0.5% MMP® Versus Topical Minoxidil 5% in the Treatment of Female Pattern Hair Loss Archives of dermatological research · 2024
    3. Botulinum Toxin A Delivery Via MMP Technique: An Emerging Therapeutic Approach for Frontal Fibrosing Alopecia Brazilian Journal of Case Reports · 2023
    4. Evaluation of Hair Regrowth After Minoxidil and Dutasteride Tattooing in Men with Androgenetic Alopecia JAAD international · 2023
    5. Female Pattern Hair Loss: Therapeutic Update Anais Brasileiros De Dermatologia · 2023
    6. Scalp Microinfusion: A Novel Drug Delivery Technique for Hair Loss Treatment Skin appendage disorders · 2023
    7. Elevation of Transaminases After MMP Session With Methotrexate for Alopecia Areata Treatment – How Much Do We Know About the Risks of Systemic Absorption of the Technique? Anais Brasileiros de Dermatologia · 2022
    8. How Much Medication Is Delivered in a Novel Drug Delivery Technique Using a Tattoo Machine? International Journal of Dermatology · 2019
    9. Male Androgenetic Alopecia Treated with Microneedling Alone or Associated with Injectable Minoxidil by Microinfusion of Drugs into the Skin Surgical and Cosmetic Dermatology · 2016