Split-Scalp Pilot Study to Evaluate Effectiveness of Minoxidil 0.5% MMP® Versus Topical Minoxidil 5% in the Treatment of Female Pattern Hair Loss

June 2024 in “ Archives of dermatological research ”

Ana Carla da Silva Corrêa, Carla Jorge Machado, Sueli Carneiro

Minoxidil Minoxidil 0.5% MMP Topical Minoxidil 5% Female Pattern Hair Loss FPHL intradermal infiltration parietal-vertex regions Rogaine

TLDR Both treatments work, but Minoxidil 0.5% MMP® is better for certain scalp areas and less advanced hair loss.

This split-scalp pilot study compared the effectiveness of Minoxidil 0.5% MMP® (intradermal infiltration) and Topical Minoxidil 5% in treating Female Pattern Hair Loss (FPHL) in 16 patients. Both treatments were generally effective, with no significant difference overall. However, Minoxidil 0.5% MMP® showed better results in the parietal-vertex regions, especially in less advanced cases of FPHL. This suggests that Minoxidil 0.5% MMP® could be a valuable treatment option for improving the quality of life in patients with FPHL.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

13 / 13 results

research Female Pattern Hair Loss: Therapeutic Update

March 2023 in “Anais Brasileiros De Dermatologia”

Topical minoxidil is the best-supported treatment for female hair loss, but personalized plans are needed.

research Scalp Microinfusion: A Novel Drug Delivery Technique for Hair Loss Treatment

January 2023 in “Skin appendage disorders”

Scalp microinfusion is a new method for treating hair loss that shows promise but needs more research for standardization.

research Minimally Invasive Procedures for the Management of Female Pattern Hair Loss

June 2022 in “Journal of Cosmetic Dermatology”

Minimally invasive procedures may help with female hair loss but need more research and should be done by experts.

research Prevalence of Female Pattern Hair Loss in a Multiracial Population

2 citations, April 2021 in “Journal of The American Academy of Dermatology”

Female pattern hair loss affects 32.3% of women, increasing with age and showing no racial differences.

research Intradermal Injections With 0.5% Minoxidil for the Treatment of Female Androgenetic Alopecia: A Randomized, Placebo-Controlled Trial

7 citations, December 2020 in “Dermatologic Therapy”

Injections with 0.5% minoxidil effectively treat female hair loss, increasing hair density and thickness.

research Novel Drug Delivery Approaches for the Management of Hair Loss

34 citations, January 2020 in “Expert opinion on drug delivery”

New methods like microneedling and nanoparticles can improve hair loss treatments.

research How Much Medication Is Delivered in a Novel Drug Delivery Technique Using a Tattoo Machine?

19 citations, March 2019 in “International Journal of Dermatology”

The tattoo machine method safely delivers an average of 1,175 µg/cm² of medication into the skin.

research Interventions for Female Pattern Hair Loss

15 citations, January 2017 in “JAMA Dermatology”

Topical minoxidil improves female pattern hair loss, finasteride not effective, laser devices show mixed results.

research Female Pattern Hair Loss: A Clinical and Pathophysiological Review

91 citations, August 2015 in “Anais Brasileiros De Dermatologia”

Female Pattern Hair Loss affects women's self-esteem and needs more research for better treatment.

research Systematic Approach to Hair Loss in Women

45 citations, March 2010 in “Journal der Deutschen Dermatologischen Gesellschaft”

A systematic approach is crucial for managing hair loss in women.

research Evaluation and Treatment of Male and Female Pattern Hair Loss

203 citations, December 2004 in “Journal of The American Academy of Dermatology”

Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.

research Telogen Effluvium: Causes, Diagnosis, and Treatment

144 citations, July 2002 in “Clinical and Experimental Dermatology”

Telogen effluvium is a common type of hair loss that can resolve on its own or become chronic, with treatment depending on early diagnosis.

research Chronic Telogen Effluvium: Increased Scalp Hair Shedding in Middle-Aged Women

234 citations, December 1996 in “Journal of The American Academy of Dermatology”

Middle-aged women with chronic telogen effluvium experience increased hair shedding but usually don't get significantly thinner hair.

Related Research

7 / 7 results

research Safety and Efficacy of Trimax-360 Serum in Healthy Adult Subjects with Mild to Moderate Alopecia of the Scalp

April 2022 in “Journal of Cosmetic Dermatology”

Trimax-360 Serum, when used for 98 days, safely and effectively improves hair growth, thickness, and density without any side effects.

Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil Treatment in Brazilian Female Pattern Hair Loss Patients

research Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil Treatment in Brazilian Female Pattern Hair Loss Patients

4 citations, December 2019 in “Dermatologic Therapy”

Hair enzyme activity predicts minoxidil success in Brazilian women with hair loss.

research Hair Loss (Alopecia or Baldness)

June 2018

Baldness is often hereditary and linked to male hormones, becoming noticeable when half the hair is lost.

research Effectiveness of Once Daily 5% Minoxidil Topical Foam in the Treatment of Women with Thinning Hair Due to Female Pattern Hair Loss

May 2015 in “Journal of The American Academy of Dermatology”

5% minoxidil foam helps women with thinning hair.

research Finasteride in the Treatment of Female Androgenic Alopecia

November 2014 in “PharmaTutor”

Finasteride may help postmenopausal women with hair loss but is not effective for all and should be used cautiously in premenopausal women.

research Treatment of Female Pattern Hair Loss with a Combination of Spironolactone and Minoxidil

21 citations, January 2007 in “Australasian Journal of Dermatology”

Spironolactone and minoxidil together effectively treat female pattern hair loss.

research Androgenetic Alopecia in Adolescents

12 citations, February 2003 in “PubMed”