Formulation and Evaluation of Repurposed Ketoconazole-Loaded Transferosomal Gel for Enhanced Trichogenic Effects

    April 2025 in “ Clinical and Translational Discovery ”
    Monu Mishra, Ganesh A. Thakur, Pallavi Bassi, Gurpreet Kaur, Thakur Gurjeet Singh, Narinderpal Kaur, Ling Shing Wong, Satyanarayana Reddy, Gowtham Kuppusamy, Vinoth Kumarasamy, Gaurav Gupta, Vetriselvan Subramaniyan
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    TLDR The ketoconazole gel improved hair growth and is a promising treatment for hair loss.
    The study developed a ketoconazole-loaded transferosomal gel to enhance hair growth and skin permeability for treating androgenic alopecia (AGA). Using a Quality by Design approach, the formulation was optimized for critical attributes like particle size and entrapment efficiency. In vivo studies on 12 male albino rats showed improved hair growth with the ketoconazole-loaded gel compared to control groups over 27 days, with no significant skin irritation. The gel demonstrated superior hair growth efficacy and sustained drug release compared to a marketed formulation, suggesting it as a promising alternative treatment for AGA.
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      community Thoughts about ORAL ketoconazole? (pills)

      in Ketoconazole 1 week ago
      Oral ketoconazole is discussed as a potential hair loss treatment, but it poses significant health risks like liver damage and adrenal insufficiency. Users suggest safer alternatives like topical anti-androgens or spironolactone, emphasizing the importance of consulting a specialist.

      community Ketoconazole shampoo, which one to choose??

      in Ketoconazole  6 upvotes 1 month ago
      Ketoconazole shampoo is recommended at a 2% concentration for hair loss, with advice to leave it in the hair for 2-5 minutes. Users discuss different brands, noting that Nizoral contains artificial dyes, and suggest alternatives without dyes.

      community 2% Ketoconazole/Nizoral Daily?

      in Ketoconazole  11 upvotes 2 months ago
      Using 2% ketoconazole daily can dry out the scalp; 1-2 times a week is recommended. Combining ketoconazole with treatments like minoxidil, alfatradiol, and fluridil can help manage hair loss effectively.

      community Does ketoconazole shampoo fry your hair ?

      in Ketoconazole  7 upvotes 3 months ago
      Ketoconazole shampoo can dry out hair, causing it to become frizzy and less manageable. Users suggest using conditioner, trying different shampoos, or reducing the frequency of ketoconazole use to mitigate these effects.

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