Formulation and Evaluation of Repurposed Ketoconazole-Loaded Transferosomal Gel for Enhanced Trichogenic Effects

    April 2025 in “ Clinical and Translational Discovery ”
    Monu Mishra, Ganesh A. Thakur, Pallavi Bassi, Gurpreet Kaur, Thakur Gurjeet Singh, Narinderpal Kaur, Ling Shing Wong, Satyanarayana Reddy, Gowtham Kuppusamy, Vinoth Kumarasamy, Gaurav Gupta, Vetriselvan Subramaniyan
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    TLDR The ketoconazole gel improved hair growth and is a promising treatment for hair loss.
    The study developed a ketoconazole-loaded transferosomal gel to enhance hair growth and skin permeability for treating androgenic alopecia (AGA). Using a Quality by Design approach, the formulation was optimized for critical attributes like particle size and entrapment efficiency. In vivo studies on 12 male albino rats showed improved hair growth with the ketoconazole-loaded gel compared to control groups over 27 days, with no significant skin irritation. The gel demonstrated superior hair growth efficacy and sustained drug release compared to a marketed formulation, suggesting it as a promising alternative treatment for AGA.
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      community What ketoconazole shampoo do you use?

      in Ketoconazole  8 upvotes 2 weeks ago
      Nizoral is commonly used for hair loss and dandruff, but it can cause dryness; users often pair it with conditioners or alternative shampoos. Some also use finasteride, minoxidil, and red light therapy for hair care.

      community What ketoconazole shampoo do you use?

      in Ketoconazole  6 upvotes 1 month ago
      Users discuss ketoconazole shampoos for hair loss, mentioning Nizoral, selsun blue, and alternatives like prescription strength options and compounded lotions to reduce dryness. Some users suggest using finasteride and minoxidil instead, questioning the cost-benefit of ketoconazole.

      community Is Ketoconazole a big factor in preventing hairloss?

      in Ketoconazole  41 upvotes 1 month ago
      Ketoconazole shampoo may help with scalp health and inflammation but is not a substitute for DHT blockers like finasteride. It is generally considered a minor addition to hair loss treatment, with varying opinions on its effectiveness.

      community Ketoconazole shampoo stopping shed

      in Ketoconazole  11 upvotes 2 months ago
      The user experienced reduced hair shedding with Ketoconazole shampoo, suggesting it may help with scalp inflammation and hair health. They also use Minoxidil and Finasteride, and suspect food intolerance and stress contribute to their hair issues.

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