A 6-Month, Prospective, Multi-Arm Study for the Efficacy of Standardized Nutraceuticals to Improve Hair Fiber Thickness and Strength

October 2025 in “ Dermatology and Therapy ”

Zoé Kececioglu Draelos, Patricia K. Farris, Adina Hazan, Isabelle Raymond‐Letron

nutraceuticals hair fiber thickness hair strength hair shaft diameter hair breakage hair shedding hair growth hair quality Nutrafol

Studysummary This study observed that adults with thinning hair who ingested a patented botanical-based supplement experienced significant increases in hair shaft diameter and reductions in hair breakage over 180 days, suggesting improved hair strength and length across various demographic groups. Our plain-language summary of this paper — not a Tressless recommendation.

This 6-month study with 252 participants assessed the efficacy of Nutrafol® nutraceuticals in improving hair fiber thickness and strength among various demographics experiencing hair thinning. By day 180, all groups showed significant increases in hair shaft diameter and reductions in hair breakage and shedding. Both investigator assessments and self-reports indicated improvements in hair strength, length, thickness, and overall health. Despite the study's open-label design and absence of a placebo group, the findings suggest that these nutraceuticals are effective interventions for enhancing hair growth and quality across diverse populations. The study was funded by Nutraceutical Wellness, Inc.

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A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of a Nutraceutical Supplement With Standardized Botanicals in Males With Thinning Hair

research A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of a Nutraceutical Supplement With Standardized Botanicals in Males With Thinning Hair

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This study suggests that addressing hormonal, stress, and metabolic factors with vitamins, minerals, and botanicals, which has improved hair growth in women, might also benefit men experiencing hair thinning.

research The Effectiveness of 675 nm Wavelength Laser Therapy in the Treatment of Androgenetic Alopecia Among Indian Patients

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research The Menopausal Transition: Is the Hair Follicle Going Through Menopause?

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In this article, researchers link menopause to hair follicle lifecycle changes, noting that estrogen decline, metabolic shifts, genetics, and stress can contribute to hair thinning and texture variation, although effects differ among women.

research Age-Associated Thin Hair Displays Molecular, Structural, and Mechanical Characteristic Changes

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research A Randomized Clinical Trial on Therapeutic Effects of 0.25 mg Oral Minoxidil Tablets on Treatment of Female Pattern Hair Loss

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Hair Diameter Measurements for Planning Follicular Unit Extraction Surgery: Is There a Correlation Between the Micrometer Caliper and Scanning Electron Microscopy Findings?

research Hair Diameter Measurements for Planning Follicular Unit Extraction Surgery: Is There a Correlation Between the Micrometer Caliper and Scanning Electron Microscopy Findings?

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In this study, the researchers found that a manual micrometer caliper is a reliable tool for planning hair transplant surgery and accurately measures the short axis of the hair shaft.

Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment

research Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment

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This study found that low-dose oral minoxidil 5 mg daily significantly increased hair growth in men with androgenetic alopecia over 24 weeks, with increased hair count and vertex area improvement, though most experienced hypertrichosis and some had pedal edema.

The Efficacy and Safety of Finasteride Combined with Topical Minoxidil for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

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research Natural Hair Supplement: Friend or Foe? Saw Palmetto, A Systematic Review in Alopecia

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research The Impact of Oxidative Stress on Hair

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research Gender Differences in Scalp Hair Growth Rates Are Maintained but Reduced in Pattern Hair Loss Compared to Controls

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This study found that individuals with patterned hair loss, both male and female, showed a slower linear hair growth rate compared to controls with hair of equal thickness.

research Role of Genetics and Sex Steroid Hormones in Male Androgenetic Alopecia and Female Pattern Hair Loss: An Update

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This review explores the current understanding of genetic and hormonal influences on male androgenetic alopecia and female pattern hair loss, providing guidance for clinicians but reports no new results.

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The study found that the break force of human hair significantly depends on hair diameter and strain, but not on age, gender, use of hair dye, or drugs.