Comparative Efficacy and Safety of Platelet-Rich Plasma, Injectable Platelet-Rich Fibrin, and Concentrated Growth Factors for Female Pattern Hair Loss: A Prospective Multicenter Randomized Clinical Trial

    April 2026 in “ Journal of Dermatological Treatment ”
    Man Li, Yue Bai, Zhenzhen Ye … Fenglin Zhuo
    Studysummary This study concluded that in female pattern hair loss patients, CGF and i-PRF treatments were more effective than PRP in increasing target area hair count, with i-PRF having the lowest adverse event rate.
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    Research cited in this study 11

    1. Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments American Journal of Clinical Dermatology · 2026
    2. Does the Transient Hair Shedding Phase Exist After Minoxidil Treatment and Predict Treatment Efficacy? A Retrospective Study in Androgenetic Alopecia Patients Journal of Dermatological Treatment · 2025
    3. New Tool in Our Arsenal: Efficacy of Injectable Platelet-Rich Fibrin in Androgenetic Alopecia Treatment Archives of Dermatological Research · 2025
    4. Evaluation of the Safety and Efficacy of Concentrated Growth Factors for Hair Growth Promotion in Androgenetic Alopecia Patients: A Retrospective Single-Center, Single-Arm Study Journal of Cosmetic Dermatology · 2024
    5. Clinical Observation and Evaluation of CGF in the Treatment of Androgenic Alopecia Journal of Cosmetic Dermatology · 2022
    6. Evaluation of Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia: A Randomized Controlled Trial Journal of The American Academy of Dermatology · 2020
    7. Platelet-Rich Plasma by Single Spin Process in Male Pattern Androgenetic Alopecia: Is It an Effective Treatment? Indian Dermatology Online Journal · 2017
    8. Minoxidil Use in Dermatology, Side Effects, and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012
    9. A Randomized, Single-Blind Trial of 5% Minoxidil Foam Once Daily Versus 2% Minoxidil Solution Twice Daily in the Treatment of Androgenetic Alopecia in Women Journal of The American Academy of Dermatology · 2011
    10. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    11. Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles Journal of Investigative Dermatology · 1995