Hyperdiluting Calcium Hydroxylapatite With Platelet-Rich Plasma and Hyaluronidase for Improving Neck Laxity and Wrinkle Severity

    July 2024 in “ Cureus
    Saami Khalifian, Alec McCarthy, Steven G Yoelin
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    Studysummary In this report, researchers observed that a single treatment using a combination of hyperdiluted calcium hydroxylapatite, platelet-rich plasma, and hyaluronidase improved neck wrinkles and skin laxity in two patients, indicating preliminary evidence for the safety and efficacy of this novel therapy.
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    The report discusses two cases where a novel injectable therapy combining hyperdiluted calcium hydroxylapatite (CaHA), platelet-rich plasma (PRP), and hyaluronidase was used to treat neck wrinkles and skin laxity. Both patients showed improvements in skin texture and laxity after a single treatment. PRP was included for its growth factors that enhance collagen production, while hyaluronidase aids in product dispersion. The study provides preliminary evidence of the therapy's safety and efficacy, marking the first use of this combination. Further research is needed to explore its application in other areas and to understand the role of each component.
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