39 citations
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June 2023 in “Frontiers in Medicine” This review found limited but suggestive evidence that Calcium Hydroxylapatite may promote skin regeneration through increased collagen production, cell proliferation, and angiogenesis, although most studies had methodological limitations.
4 citations
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July 2024 in “Cureus” In this report, researchers observed that a single treatment using a combination of hyperdiluted calcium hydroxylapatite, platelet-rich plasma, and hyaluronidase improved neck wrinkles and skin laxity in two patients, indicating preliminary evidence for the safety and efficacy of this novel therapy.
1 citations
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August 2024 in “Lasers in Surgery and Medicine” This study observed that calcium hydroxylapatite can be successfully incorporated and retained in the dermis for at least six weeks after fractional laser treatment, with new collagen forming around it.
15 citations
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March 2015 in “Facial plastic surgery” This article series reviews volumetric restoration techniques for different facial regions by expert authors, offering assessments of specific products but provides no new clinical results.
6 citations
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April 2018 in “Facial Plastic Surgery” This article reviews methods for temple region rejuvenation and reports no new clinical results; the authors emphasize the importance of understanding temple anatomy for optimal aesthetic outcomes.