Apoptotic Cells Represent a Dynamic Stem Cell Niche Governing Proliferation and Tissue Regeneration

June 2021 in “ Developmental Cell ”

Roi Ankawa, Nitzan Goldberger, Yahav Yosefzon, Elle Koren, Marianna Yusupova, Daniel Rösner, Alona Feldman, Shulamit Baror-Sebban, Yosef Buganim, David Simon, Marc Tessier‐Lavigne, Yaron Fuchs

caspase-9 hair follicle stem cells HFSCs apoptosis proliferation tissue regeneration Wnt3 caspase-3 Dusp8 p38 wound repair hair follicles

Studysummary In this study, researchers found that deleting Caspase-9 in hair follicle stem cells delayed apoptosis, leading to accelerated wound repair and new hair follicle regeneration by maintaining apoptotic cells as signaling centers.

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