Endocrinology of the Aging Prostate: Current Concepts

February 2021 in “ Frontiers in Endocrinology ”

Rossella Cannarella, Rosita A. Condorelli, Federica Barbagallo, Sandro La Vignera, Aldo E. Calogero

Studysummary This review explores the potential impact of hormonal changes during aging on benign prostate hyperplasia-related urinary symptoms and metabolic syndrome, highlighting the hypothesis of a male PCOS-equivalent but reports no new clinical results.

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Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?

research Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?

9 citations , February 2020 in “International Journal of Endocrinology”

This study found that men with early-onset androgenetic alopecia and certain risk factors may have worse gonadal steroidogenesis and an increased likelihood of developing gonadal dysfunction, suggesting a male equivalent of polycystic ovarian syndrome.

research Glycolipid and Hormonal Profiles in Young Men with Early-Onset Androgenetic Alopecia: A Meta-Analysis

15 citations , August 2017 in “Scientific Reports”

This study found that young men with early-onset androgenetic alopecia have a worse glycolipid profile and hormone pattern similar to women's PCOS, suggesting a possible male PCOS-equivalent syndrome.

research Does a Male Polycystic Ovarian Syndrome Equivalent Exist?

28 citations , July 2017 in “Journal of Endocrinological Investigation”

This study suggests that early onset androgenetic alopecia in men may indicate a male PCOS equivalent, possibly leading to higher risks of metabolic and cardiovascular disorders later in life.

Androgenetic Alopecia and Polymorphism of the Androgen Receptor Gene (SNP rs6152) in Patients with Benign Prostate Hyperplasia or Prostate Cancer

research Androgenetic Alopecia and Polymorphism of the Androgen Receptor Gene (SNP rs6152) in Patients with Benign Prostate Hyperplasia or Prostate Cancer

11 citations , March 2014 in “Journal of The European Academy of Dermatology and Venereology”

In this study, researchers found that androgen receptor gene polymorphism is associated with higher androgenetic alopecia grades and PSA levels in men with benign prostatic hyperplasia, but not with prostate cancer.

research Association of Androgenetic Alopecia With Mortality From Diabetes Mellitus and Heart Disease

49 citations , May 2013 in “JAMA Dermatology”

This study found that moderate to severe androgenetic alopecia is an independent predictor of increased mortality risk from diabetes mellitus and heart disease in both sexes.

research Androgenetic Alopecia and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis

34 citations , February 2013 in “Journal of The American Academy of Dermatology”

This meta-analysis found that vertex pattern androgenetic alopecia was associated with an increased risk of developing prostate cancer, while other androgenetic alopecia patterns did not show a significant link.

research Androgenetic Alopecia as an Early Marker of Benign Prostatic Hyperplasia

5 citations , September 2012 in “The Journal of Urology”

This article discusses androgenetic alopecia as a potential early marker for benign prostatic hyperplasia but reports no new clinical findings.

research Androgenetic Alopecia as an Early Marker of Benign Prostatic Hyperplasia

28 citations , August 2011 in “Journal of The American Academy of Dermatology”

This study found that men with early-onset androgenetic alopecia had significantly larger prostate volumes and lower urinary flow rates compared to healthy controls, suggesting a possible link between AGA and prostate-related urinary symptoms.

research Patients With a Large Prostate Show a Higher Prevalence of Androgenetic Alopecia

4 citations , November 2005 in “The Journal of Urology”

In this study, patients with larger prostates were observed to have a higher prevalence of androgenetic alopecia.

research Patients With a Large Prostate Show a Higher Prevalence of Androgenetic Alopecia

33 citations , October 2004 in “Archives of Dermatological Research”

This study suggests that a larger prostate is associated with a higher prevalence of androgenetic alopecia, although the prostate size did not correlate with alopecia severity.

research Dihydrotestosterone and the Concept of 5-Alpha-Reductase Inhibition in Human Benign Prostatic Hyperplasia

184 citations , January 2000 in “European Urology”

This abstract reviews the role of finasteride and potential dual 5alpha-reductase inhibitors in treating benign prostatic hyperplasia, suggesting that dual inhibitors may offer greater DHT suppression and therapeutic advantages, while emphasizing the need for clinical evaluation.

research Association of Benign Prostatic Hyperplasia with Male Pattern Baldness

54 citations , May 1998 in “Urology”

This study demonstrates that patients with benign prostatic hyperplasia have a higher severity and frequency of male pattern baldness compared to a control group.