April 2017 in “Journal of Investigative Dermatology” This study found that human iPSC-derived dermal papilla precursor cells can regenerate hair follicle structures, offering a potential new treatment approach for permanent alopecia.
37 citations
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April 2017 in “npj Regenerative Medicine” This study found that platelet-derived growth factor signaling is crucial for maintaining the hair follicle dermal stem cell pool and supporting their regenerative capacity.
6 citations
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January 2016 in “Methods in molecular biology” This protocol describes a method for regenerating hair follicles using a bioengineering technique called the Organ Germ Method, but it reports no new clinical results.
321 citations
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December 2009 in “Journal of Dermatological Science” This review discusses the role of dermal cells in hair follicle regeneration and morphogenesis and highlights their potential therapeutic implications, but it reports no new empirical findings.
61 citations
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November 2004 in “Annals of the Academy of Medicine Singapore” This review examines the location and markers of hair follicle stem cells, finding that they are primarily located in the bulge region and can contribute to various skin structures, but challenges remain in distinguishing them from their progeny.
90 citations
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August 2004 in “Physiological Genomics” This study found that coculturing human hair follicle keratinocyte stem cells with dermal papilla cells increased expression of the hair-specific keratin 6hf gene, which requires β-catenin/lef-1 signaling for hair differentiation.
January 2003 in “Chinese Journal of Reparative and Reconstructive Surgery” This study found that dermal papilla cells and dermal sheath fibroblasts can induce hair follicle formation when combined with hair follicle epithelial cells, both in vitro and in vivo in nude mice.
66 citations
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August 2001 in “Experimental Dermatology” This study demonstrated that intact adult human dermal papillae can induce hair growth when implanted into mouse hair follicles, highlighting their potential for advancing hair follicle biology and therapeutic approaches.
24 citations
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January 1989 This research discusses the function and culture of human dermal papilla cells, noting their unique in vitro characteristics and the ongoing efforts to understand their role in inducing hair growth.