here is why isotretinoin might cause hair loss and maybe why dupa happens.
Research/Science 6/30/2023
isotretinoin DHT DHEAS topical antiandrogens RU58841 pyrilutamide PPAR-y expression pioglitazone telogen effluvium 5AR inhibitors finasteride oestrodial aromatase keratosis pilaris keratin Accutane Dihydrotestosterone Dehydroepiandrosterone sulfate Propecia Estrogen
Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.
View this post in the Community →
Similar Community Posts Join
5 / 32 resultscommunity Oral min and Isotretinoin (accutane) to respond
Oral minoxidil combined with isotretinoin may improve hair loss treatment effectiveness. Tretinoin is known to increase the absorption of topical minoxidil.
community Which retinoid for better min absorption?
User is on vacation in Greece and wants to buy tretinoin or isotretinoin to improve Minoxidil absorption. They are considering isotretinoin since it is available over-the-counter in Greece but requires a prescription back home.
community Dut/Minox/Needling to Dut/Oral Minox/Tretinoin/Needling
The user had been using Minoxidil and Dutasteride with micro-needling but experienced hair loss after switching Minoxidil brands. Their doctor prescribed oral Minoxidil and Tretinoin, but the pharmacist suggested isotretinoin might be a more cost-effective alternative.
community Seborrheic dermatitis - can it cause long-term shedding (or telogen effluvium)?
A user is experiencing significant hair loss and scalp issues despite using Minoxidil, finasteride, and RU58841 since 2017. They switched to oral Minoxidil and are now on isotretinoin and topical corticosteroids for seborrheic dermatitis but continue to lose hair and seek advice on whether inflammation or treatment changes are the cause.
community Correlation between topical retinoids and diffuse hair loss
Excess Vitamin A and topical retinoids can cause diffuse hair shedding. The user suspects their chronic telogen effluvium may be linked to using adapalene, a topical retinoid.
Related Research
6 / 1000+ results
research Action of Isotretinoin in Acne Rosacea and Gram-Negative Folliculitis
Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.
research Isotretinoin Treatment of Acne and Related Disorders: An Update
Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.
research Adverse Effects of Isotretinoin: A Retrospective Review of 1743 Patients
Most people on isotretinoin had chapped lips, but only a few stopped the medicine due to side effects.
research Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity
Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.
research Oral Isotretinoin for Acne
Oral isotretinoin may slightly improve acne but increases the risk of side effects like dry lips and skin; more research is needed to understand its full risks and benefits.
research Enduring Sexual Dysfunction After Treatment With Antidepressants, 5α-Reductase Inhibitors, and Isotretinoin: 300 Cases
Antidepressants, 5α-reductase inhibitors, and isotretinoin can cause long-lasting sexual dysfunction.