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GlossaryTCF4 (Transcription Factor 4)

regulates gene expression crucial for nervous system development

TCF4, or Transcription Factor 4, is a protein that plays a crucial role in regulating the expression of genes involved in various biological processes, including cell growth, differentiation, and development. It is particularly important in the development of the nervous system and has been implicated in several neurological disorders.

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All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

research Dynamic Morphogen-p63 Chromatin Interactions That Guide Epigenetic Changes and p63 Activity in Surface Ectoderm Commitment

April 2018 in “Journal of Investigative Dermatology”

The study found that p63 needs signals from morphogens to help skin cells differentiate properly.

research Requirement of Zinc Transporter ZIP10 for Epidermal Development: Implication of the ZIP10–p63 Axis in Epithelial Homeostasis

59 citations , October 2017 in “Proceedings of the National Academy of Sciences”

ZIP10 is crucial for skin development and maintaining healthy skin.

research Np63 Regulates Stem Cell Dynamics in the Mammalian Olfactory Epithelium

93 citations , June 2011 in “Journal of Neuroscience”

p63 is essential for activating and differentiating stem cells in the nose's olfactory tissue.

research The Developmental and Molecular Requirements for Ensuring That Human Pluripotent Stem Cell-Derived Hair Follicle Bulge Stem Cells Have Acquired Competence for Hair Follicle Generation Following Transplantation

4 citations , January 2021 in “Cell transplantation”

Scientists found the best time to transplant human stem cells for hair growth is between days 16-18 when they have the right markers and growth potential.

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community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 59 upvotes 2 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Why is nobody studying the difference between donor and balding hair?

in Chat 89 upvotes 1 year ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Fats on your Head to Stop Hair Loss?

in Research/Science 140 upvotes 1 year ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 2 years ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

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