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GlossaryTCF4 (Transcription Factor 4)

regulates gene expression crucial for nervous system development

TCF4, or Transcription Factor 4, is a protein that plays a crucial role in regulating the expression of genes involved in various biological processes, including cell growth, differentiation, and development. It is particularly important in the development of the nervous system and has been implicated in several neurological disorders.

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Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Reveal Etiological Insights Into Genetic Risk for Hair and Skin Disease

research Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Reveal Etiological Insights Into Genetic Risk for Hair and Skin Disease

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

The research provided new insights into the genetic factors contributing to hair loss and skin conditions by analyzing individual cells from the human scalp.

research The Pioneer Factor SOX9 Competes for Epigenetic Factors to Switch Stem Cell Fates

6 citations, July 2023 in “Nature cell biology”

SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.

research GRHL3 Binding and Enhancers Rearrange as Epidermal Keratinocytes Transition Between Functional States

38 citations, April 2017 in “PLOS Genetics”

GRHL3 is important for controlling gene activity in skin cells during different stages of their development.

research Stem Cells Tightly Regulate Dead Cell Clearance to Maintain Tissue Fitness

2 citations, May 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Stem cells help remove dead cells to keep tissues healthy by balancing cell replacement and clearance.

research Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium

181 citations, February 2019 in “Cell”

Innate lymphoid cells help control skin bacteria by regulating sebaceous glands.

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community Why is nobody studying the difference between donor and balding hair?

in Chat 89 upvotes 5 months ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Fats on your Head to Stop Hair Loss?

in Research/Science 138 upvotes 9 months ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 40 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community What happened to the ‘funding’ for broccoli research in treating hair loss?

in Chat 42 upvotes 3 years ago

Hair loss discussion includes broccoli sprouts treatment, Fluridil 7%, and sulforaphane, with mixed results. Finasteride, minoxidil, and RU58841 are preferred by some users.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 122 upvotes 6 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

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