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    Glossary Transcription Factors

    proteins that regulate gene expression by binding to DNA

    Transcription Factors (TFs) are proteins that help turn specific genes on or off by binding to nearby DNA. They play a crucial role in regulating gene expression, ensuring that genes are activated at the right time and in the right cells, which is essential for processes like development, cell growth, and response to environmental signals.

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    Research 30 of 1000+

    1. SlPHL1, a MYB‐CC transcription factor identified from tomato, positively regulates the phosphate starvation response Physiologia Plantarum · 2021 · 11 citations
    2. Integrated single-cell chromatin and transcriptomic analyses of human scalp reveal etiological insights into genetic risk for hair and skin disease bioRxiv (Cold Spring Harbor Laboratory) · 2022
    3. Allosteric interactions prime androgen receptor dimerization and activation bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 1 citations
    4. Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders Frontiers in Immunology · 2020 · 20 citations
    5. Langerin+ Dendritic Cells in Cutaneous Fibrosis: The TGF-β1 Signaling Axis Clinical Cosmetic and Investigational Dermatology · 2025
    6. The function of TRPS1 in the development and differentiation of bone, kidney, and hair follicles. PubMed · 2011 · 52 citations
    7. 164 Epigenetic and transcriptional profiling of PBMCs in mild and severe alopecia areata using single-cell RNA-Seq and ATAC-Seq Journal of Investigative Dermatology · 2023
    8. Role of Csdc2 in Regulating Secondary Hair Follicle Growth in Cashmere Goats International Journal of Molecular Sciences · 2024 · 2 citations
    9. HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression Journal of Biological Chemistry · 2002 · 132 citations
    10. In Silico Promoter Motif Analysis of Human Fertility-Related Genes Applied Biosciences · 2026
    11. Arabidopsis ZINC FINGER PROTEIN1 Acts Downstream of GL2 to Repress Root Hair Initiation and Elongation by Directly Suppressing bHLH Genes The Plant Cell · 2019 · 101 citations
    12. Pmg-1 and Pmg-2 constitute a novel family of KAP genes differentially expressed during skin and mammary gland development Mechanisms of Development · 1999 · 22 citations
    13. AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    14. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    15. WRKY transcription factors (TFs): Molecular switches to regulate drought, temperature, and salinity stresses in plants Frontiers in Plant Science · 2022 · 179 citations
    16. Runx1 transcription factor is involved in the regulation of KAP5 gene expression in human hair follicles Journal of dermatological science · 2006 · 6 citations
    17. Dynamic expression of the zinc-finger transcription factor Trps1 during hair follicle morphogenesis and cycling Gene Expression Patterns · 2007 · 46 citations
    18. Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome American journal of human genetics · 2020 · 34 citations
    19. The transcription elongation factors Spt4 and Spt6 promote dermal adipocyte differentiation Adipocyte · 2026
    20. AabHLH112, a bHLH transcription factor, positively regulates sesquiterpenes biosynthesis in Artemisia annua Frontiers in Plant Science · 2022 · 19 citations
    21. AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis 2024
    22. Prediction of cell states and key transcription factors of the human cornea through integrated single-cell omics analyses PNAS Nexus · 2025
    23. The complex relationship between TFEB transcription factor phosphorylation and subcellular localization EMBO journal · 2018 · 344 citations
    24. Function of KLF4 in Stem Cell Biology InTech eBooks · 2013 · 5 citations
    25. Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells Frontiers in Cell and Developmental Biology · 2020 · 8 citations
    26. The Harmonies Played by TGF-β in Stem Cell Biology Cell Stem Cell · 2012 · 156 citations
    27. The promoter of an androgen dependent gene in the hamster flank organ Journal of Dermatological Science · 1997 · 6 citations
    28. Decision letter: ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas 2015
    29. Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation Frontiers in Cell and Developmental Biology · 2026
    30. The Rho GTPase exchange factor Vav2 promotes extensive age-dependent rewiring of the hair follicle stem cell transcriptome Frontiers in cell and developmental biology · 2023